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Safety Evaluation of the High-Dose Intake of Heat-Killed <i>Lacticaseibacillus paracasei</i>MCC1849 in Healthy Adults. [PDF]
Wada N +7 more
europepmc +1 more source
Safety evaluation of the food enzyme aspergillopepsin I from the genetically modified <i>Trichoderma reesei</i> strain DP-Nzq40. [PDF]
EFSA Panel on Food Enzymes (FEZ) +16 more
europepmc +1 more source
Safety Evaluation of Fine Bubble Shower Washing for Patients With Atopic Dermatitis: A Double-Blind, Randomized, Prospective Crossover Clinical Trial. [PDF]
Kato H +9 more
europepmc +1 more source
HAZOP and SEQHAZ® methods as input data producers to Safety Integrity Level evaluations
Daniel Björkhem
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2013
Before pharmaceutical products are evaluated in humans, it is essential that they undergo a rigorous safety assessment using in vitro models and studies in preclinical species. Once products progress into the clinic, additional preclinical studies are needed to support further clinical testing.
Jonathon D S, Holt, Jeremy P, Nuttall
openaire +2 more sources
Before pharmaceutical products are evaluated in humans, it is essential that they undergo a rigorous safety assessment using in vitro models and studies in preclinical species. Once products progress into the clinic, additional preclinical studies are needed to support further clinical testing.
Jonathon D S, Holt, Jeremy P, Nuttall
openaire +2 more sources
Journal of Safety Research, 2005
In most countries, drivers licensing systems usually include teaching some aspects of using safety equipment (e.g., airbags and seat belts). However, there is now evidence worldwide that such education is inadequate, as indicated by, for example, the overrepresentation of young drivers who do not use seat belts.A randomized controlled study was ...
Anders, Nyberg +3 more
openaire +2 more sources
In most countries, drivers licensing systems usually include teaching some aspects of using safety equipment (e.g., airbags and seat belts). However, there is now evidence worldwide that such education is inadequate, as indicated by, for example, the overrepresentation of young drivers who do not use seat belts.A randomized controlled study was ...
Anders, Nyberg +3 more
openaire +2 more sources
Food and Chemical Toxicology, 1993
Esperase is a proteolytic enzyme preparation that can be used as a processing aid in the food industry. The following studies were performed to establish safety for the consumer: oral toxicity study (13 wk) in the rat; teratogenicity study in the rat; gene mutation assays in Salmonella typhimurium and mammalian cells in vitro, and chromosome aberration
R K, Hjortkjaer +6 more
openaire +2 more sources
Esperase is a proteolytic enzyme preparation that can be used as a processing aid in the food industry. The following studies were performed to establish safety for the consumer: oral toxicity study (13 wk) in the rat; teratogenicity study in the rat; gene mutation assays in Salmonella typhimurium and mammalian cells in vitro, and chromosome aberration
R K, Hjortkjaer +6 more
openaire +2 more sources
Safety evaluation of tirofiban
Expert Opinion on Drug Safety, 2010Heightened platelet activity is pivotal in the thrombosis underlying acute coronary syndrome (ACS). The glycoprotein IIb/IIIa inhibitor tirofiban is a powerful platelet inhibitor with demonstrated efficacy and safety across the spectrum of ACS. Despite tirofiban's impact on the platelet compared with placebo, only an excess in minor and importantly not
Marco, Valgimigli, Matteo, Tebaldi
openaire +2 more sources
Safety evaluation of fibermalt
Food and Chemical Toxicology, 2012Fibermalt is a new soluble fiber food ingredient produced with the use of an alternansucrase enzyme from Leuconostoc mesenteroides expressed in a non-pathogenic strain of Escherichia coli. Fibermalt is predominantly composed of indigestible maltose alternan oligosaccharides (≥ 80%). Fibermalt was non-mutagenic in a bacterial reverse mutation test. In a
Laurie C, Dolan +5 more
openaire +2 more sources

