Results 81 to 90 of about 3,112,326 (355)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Demand for public safety [PDF]

In public safety of less concern to poor people? What about people in poor areas? How is demand for public safety affected by income inequality? Is there a self-correcting mechanism whereby higher crime increases demand for public safety?
Pradhan, Menno, Ravallion, Martin
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

SAFETY-J: Evaluating Safety with Critique

Findings of the Association for Computational Linguistics: EMNLP 2024
The deployment of Large Language Models (LLMs) in content generation raises significant safety concerns, particularly regarding the transparency and interpretability of content evaluations. Current methods, primarily focused on binary safety classifications, lack mechanisms for detailed critique, limiting their utility for model improvement and user ...
Liu, Yixiu, Zheng, Yuxiang, Xia, Shijie, Li, Jiajun, Tu, Yi, Song, Chaoling, Liu, Pengfei   +6 more
openaire   +2 more sources

Evaluation of safety of Azdirachta indica seed oil on Albino rat through haematological and some antioxidants by the rotatable central composite design (RCCD) of the response surface methodology (RSM) [PDF]

, 2018
Raw Azdirachta indica seed oil is gradually adopted by local farmers as a protector of stored grains and legumes against the common insects, but with some reservations on its safety. The study investigated the safety A.
G, U. P. (Udofia), Phillippa, O. (Ojimelukwe), Ukom, A. (Anthony)   +2 more
core  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Safety Evaluation of Critical Applications Distributed on TDMA-Based Networks [PDF]

, 2006
Critical embedded systems have to provide a high level of dependability. In automotive domain, for example, TDMA protocols are largely recommended because of their deterministic behavior. Nevertheless, under the transient environmental perturbations, the
Simonot, François, Simonot-Lion, Françoise, Song, Ye-Qiong   +2 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source