Results 61 to 70 of about 1,128,069 (317)

Repeat-dose toxicity of human umbilical cord mesenchymal stem cells via subcutaneous injection in NOG mice

Frontiers in Cell and Developmental Biology
BackgroundStem cell therapy shows promise for treating skin diseases and enhancing medical aesthetics. However, safety data for subcutaneous injection of stem cells remain limited.
Lijuan Xia, Jinjin Shao, Qian Yang, Chengda Zhang, Zhiqi Xie, Linying Wang, Cong Xu, Siming Zhang, Jing Liu, Jing Liu, Fang Liu, Fang Liu, Yuhua Shi, Liqiang Gu, Xiaobo Lin, Jiahong Wang, Ying Chen, Yunxiang Chen, Xin Pan, Feifei Wu, Ruolang Pan, Jinfeng Liang, Lijiang Zhang, Lijiang Zhang   +23 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Human umbilical cord mesenchymal stem cell therapy for atopic dermatitis through inhibition of neutrophil chemotaxis

Stem Cell Research & Therapy
Background Atopic dermatitis (AD) management is significantly challenging due to the high prevalence, chronicity, and recurrent nature of the disease, and limited options for its treatment.
Jinjin Shao, Zhiqi Xie, Zhichao Ye, Guoyu Chen, Yiru Wang, Lili Zhang, Fang Liu, Siming Zhang, Xiaobo Lin, Jiahong Wang, Ying Chen, Yunxiang Chen, Xin Pan, Feifei Wu, Ruolang Pan, Jinfeng Liang, Lijiang Zhang   +16 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Establishing Confidence in Safety Assessment Evidence [PDF]

, 2012
With the increased complexity and higher safety commitment of modern safety–critical systems, safety assessment models of these systems are increasingly complicated and obscure.
Sun, Linling
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

An evaluation of Aveda Corporation's environmental and safety management system (ESMS) orientation/inudction training in an ISO 14001 framework [PDF]

, 2004
Plan BThe purpose of this study was to evaluate the effectiveness of Aveda Corporation’s Environmental and Safety Management System (ESMS) Orientation/Induction training for manufacturing operations employees at the Blaine, MN facility.
Boysen, Stephanie Ann Van Dyke
core  

Bio-distribution and toxicity potential of human umbilical cord mesenchymal stem cells in cynomolgus monkeys

Scientific Reports
Mesenchymal stem cells (MSCs) have demonstrated promising advantages in the therapies of many diseases, while its multi-directional differentiation potential and immunotoxicity are the major concerns hindered their clinical translation.
Ying Huang, Xiaofang Hao, Zhi Lin, Lulu Li, Hua Jiang, Hezhan Zhang, Xingchao Geng, Hao Zhu, Hairuo Wen   +8 more
doaj   +1 more source

Developmental and reproductive toxicity assessment of sporoderm-removed Ganoderma lucidum spores

Frontiers in Cell and Developmental Biology
IntroductionGanoderma lucidum is a fungus used in traditional Chinese medicine with high medicinal value and is also widely used in modern healthcare. Its spores are reported to contain antitumor and anti-inflammatory properties, among other biological ...
Junxiu Liu, Yisheng Song, Yisheng Song, Chuanhuai Chen, Jing Liu, Jing Liu, Siming Zhang, Fang Liu, Fang Liu, Ruiyu Tian, Jinjin Shao, Lili Zhang, Tingli Bian, Ruimin Sun, Li Yu, Shuizhen Pan, Yunxiang Chen, Yaoxian Xuan, Hanbo Wang, Zhenhao Li, Ying Chen, Lijiang Zhang, Lijiang Zhang   +22 more
doaj   +1 more source