Results 151 to 160 of about 7,677,659 (304)

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source

New insights on the cardiac safety factor: Unraveling the relationship between conduction velocity and robustness of propagation. [PDF]

J Mol Cell Cardiol, 2019
Boyle PM, Franceschi WH, Constantin M, Hawks C, Desplantez T, Trayanova NA, Vigmond EJ.   +6 more
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Capability of safety climate to predict construction safety outcomes

, 2012
Safety climate refers to the degree to which employees believe that true priority is given to organizational safety performance. It is thought to be measured through a set of underlying factors such as management commitment.
Teo Ai Lin, Evelyn, Y Feng (7936262), Feng, Yingbin (R16766), Wu, Peng, A Teo (9880331), Peng Wu (9847019)   +5 more
core  

Research on the Determination Method of Additional Safety Factor Margin for Ultradeep Well Pipe Strings under Multisource Loads. [PDF]

ACS Omega
Gao Y, Zhang H, Li X, Wu B, Chen Q, Cai B, Zhang H.   +6 more
europepmc   +1 more source

A novel method to estimate safety factor of capture by a fetal micropacemaker. [PDF]

Physiol Meas, 2016
Vest AN, Zhou L, Bar-Cohen Y, Eli Loeb G.   +3 more
europepmc   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Multi-strategy quantum-inspired dung beetle optimizer for kernel extreme learning machine in slope safety factor prediction. [PDF]

Sci Rep
Sun Z, Hai M, Wang M, Guo Y, Zhou B, Zhang Q.   +5 more
europepmc   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Frugal engineering of a jaw crusher using the factor-of-frugality, a modern version of the safety-factor. [PDF]

PLoS One
Krishnan A, Rao BC.
europepmc   +1 more source