Results 51 to 60 of about 323,756 (267)
Integrated therapy safety management system [PDF]
British Journal of Clinical Pharmacology, 2013 AimsThe aim is to demonstrate the benefit of the medico‐ergonomic approach for the redesign of clinical work systems. Based on the six layer model, a concept for an ‘integrated therapy safety management’ is drafted. This concept could serve as a basis to improve resilience.MethodsThe concept is developed through a concept‐based approach.
Beatrice, Podtschaske +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Rapid Integration of CPS Security and Safety [PDF]
IEEE Embedded Systems Letters, 2019 The security and safety of Cyber-Physical Systems (CPS) often influence each other. Ensuring that this does not have negative implications might require a large and rigorous effort during the development of CPS. However, early in the life-cycle, quick feedback can be valuable helping security and safety engineers to understand how seemingly trivial ...
Fredrik Asplund +3 more
openaire +3 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Izvestiya MGTU MAMI, 2016 The paper analyzes issues of vehicle structural safety regulated by international UN rules in order to reduce the number of road accidents and particularly the severity of their consequences. The effectiveness of the UN Rules for reduction of road accidents is analyzed and especially the number of killed and injured in accidents on the roads is studied.
V. K. Azarov +2 more
openaire +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Safety Integrity Problems Reviews of Rail Transit Vehicle System
机车电传动, 2015 Aiming to the deviations and mistakes of the standardization and system of RAMS had been carried out comprehensively in the field of rail transportation, and the problems of some systems excessive pursuit of so-called security intergrity, the risk ...
GUO Qiyi +3 more
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