Results 41 to 50 of about 251,357 (265)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Development of an Algorithm for a National Microprocessor-Based Centralization System With a Modular Architecture KZ-MPC-MA Featuring Advanced Intelligent Control Functions

IEEE Access
This article analyzes the current state of railway automation and telemechanics systems operating on the railway network of Kazakhstan. It identifies their critical indicators in terms of operational lifespan and reveals key issues within the mainline ...
Kanibek M. Sansyzbay, Yelena A. Bakhtiyarova, Teodor Iliev, Gennady S. Patokin, Laura T. Tasbolatova, Daniyar B. Sagmedinov   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Attacks to Cryptography Protocols of Wireless Industrial Communication Systems

Advances in Electrical and Electronic Engineering, 2010
The paper deals with problems of safety and security principles within wireless industrial communication systems. First safety requirements to wireless industrial communication system, summarisation of attack methods and the available measures for risks ...
Tomas Ondrasina, Maria Franekova
doaj  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

ASIL determination for motorbike’s Electronics Throttle Control System (ETCS) mulfunction

EPJ Web of Conferences, 2017
Electronics Throttle Control System (ETCS) is the principal electronic unit in all fuel injection engine motorbike, augmenting the engine performance efficiency in comparison to the conventional carburetor based engine.
Rokhani Fakhrul Zaman, Abdul Rahman Muhammad Taqiuddin, Kamsani Noor Ain, Mohd Sidek Roslina, Saripan M Iqbal, Samsudin Khairulmizam, Hassan Mohd Khair   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

SIL Determination: Dealing with the Unexpected

Chemical Engineering Transactions, 2013
The International Standards for Functional Safety (IEC 61508 and IEC 61511) are well recognised and have been adopted globally in many of the industrialised countries during the past 10 years or so. Conformance with these standards involves determination
A. King
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source