Results 61 to 70 of about 251,357 (265)
Effect of terahertz irradiation on DNA damage repair in living cells
FEBS Open Bio, EarlyView.We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno +3 more
wiley +1 more source
ON THE CONCEPT OF SAFETY INSTRUMENTED SYSTEMS
Visión Electrónica, 2014 This paper presents a concrete definition of what a Safety Instrumented System (SIS) is. This involves important concepts such as risk, safety integrity level, SIL, life cycle and protection layer.
Luis Efrén Barrero Páez +2 more
doaj
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Functional safety of traction railway rolling stock
Вестник Научно-исследовательского института железнодорожного транспорта, 2016 The article describes approaches to the definition of functional safety in railway transport. The importance of compliance with requirements for functional safety in the context of widespread use of programmable controllers and microprocessor control ...
V. A. Kuchumov +4 more
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Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Chemical Engineering Transactions, 2012 Recent accidents with a catastrophic impact on Safety and Environment in the Oil & Gas (O&G) and Oil Refining industries has prompted the Regulators and the Process industry to move an important step forward to ensure to the Communities and the industry ...
P. Fanelli
doaj +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Modeling and Simulation of On-board ATP Controlling Module for Train Operation Control System
Kongzhi Yu Xinxi Jishu, 2018 The automatic train protection(ATP) system provides complete over-speed protection for train, which obtains superior security classification. The transform relationship of ATP modules was studied and a modeling development method was proposed which ...
ZHANG Xu, LIU Hao, LUO Liyan
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Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source