Results 91 to 100 of about 4,898,935 (299)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Elderly versus younger patients with hereditary angioedema type I/II: patient characteristics and safety analysis from the Icatibant Outcome Survey

Clinical and Translational Allergy, 2019
Background Hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) is characterized by recurrent swelling in subcutaneous or submucosal tissues.
Anette Bygum, Teresa Caballero, Anete S. Grumach, Hilary J. Longhurst, Laurence Bouillet, Werner Aberer, Andrea Zanichelli, Jaco Botha, Irmgard Andresen, Marcus Maurer, for the IOS Study Group   +10 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Safety Culture and Patient Safety Outcomes in East Asia: A Literature Review

Western Journal of Nursing Research, 2019
This review examined associations between safety culture aspects and patient safety outcomes in East Asian hospitals and identified relevant research priorities. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, 16 articles were identified for review.
Seung Eun Lee, Brenna L. Quinn
openaire   +3 more sources

Process Safety for OHS Professionals [PDF]

, 2016
PresentationProcess safety is a field dominated by engineers and OHS professionals come from a range of different disciplines. In addition to this process safety is often managed by engineers outside of the traditional safety function.
Kerin, Trish
core   +1 more source

NIOSH Public Safety Program [PDF]

"What are our priorities? The National Institute for Occupational Safety and Health (NIOSH) Public Safety Program works with partners in industry, labor, trade associations, professional organizations, and academia.

core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Assessing the impact of nurses’ patient safety competencies on key performance indicators (KPIs) for patient safety outcomes at Tamale Teaching Hospital: the mediating role of leadership and barriers to competency development

BMC Health Services Research
Introduction Despite significant advancements in healthcare, patient safety remains a persistent global concern. Nurses’ competency in patient safety is essential for minimizing errors and improving key performance indicators (KPIs) related to patient ...
Mudasir Mohammed Ibrahim, Fatima Abdul-Rahaman, Mohammed Sherif Sayibu, Dora Nyamekye Alhassan, Ruhaima Tunteya Awudu, Iddrisu Mohammed Sisala, Abubakari Wuni, Abdul-Malik Abdulai   +7 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Predictive analytics in autonomous vehicles safety: crash outcome modeling

Urban, Planning and Transport Research
Traffic-related fatalities, often caused by human error, present a global challenge. Autonomous vehicles (AVs), designed to reduce these fatalities by eliminating human error, still experience crashes. Prior research, limited by the scope of the data set
Sai Sneha Channamallu, Deema Almaskati, Sharareh Kermanshachi, Apurva Pamidimukkala   +3 more
doaj   +1 more source