Results 81 to 90 of about 2,284 (202)

Cytotoxicity of safrole in HepaRG cells: studies on the role of CYP1A2-mediated ortho-quinone metabolic activation

, 2019
1. Safrole is a natural compound categorized as a group 2B carcinogen extracted from sassafras oil or certain other essential oils. The hepatotoxicity of safrole has always been highly concerned.
Yifan Song (2537101), Jie He (132999), Hua Shao (295138), Linlin Hu (331140), Fei Wu (117860), Lingjun Zhong (6856829)   +5 more
core   +1 more source

(+)-Erythro-Δ^8′-7S,8R-dihydroxy-3,3′,5′-trimethoxy-8-O-4′-neolignan, an Anti-Acne Component in Degreasing Myristica fragrans Houtt

Molecules, 2020
Acne is a common skin condition observed in adolescents. Nutmeg (Myristica fragrans Houtt) (MF) is a well-known traditional Chinese medicine; its major toxic components, safrole and myristicin, are rich in essential oils.
Chia-Jung Lee, Chun-Wei Huang, Lih-Geeng Chen, Ching-Chiung Wang   +3 more
doaj   +1 more source

Human cytochrome P450 enzyme specificity for bioactivation of safrole to the proximate carcinogen 1'-hydroxysafrole

, 2004
In the present study, the cytochrome P450 mediated bioactivation of safrole to its proximate carcinogenic metabolite, 1'-hydroxysafrole, has been investigated for the purpose of identifying the human P450 enzymes involved. The 1'-hydroxylation of safrole
Bogaards, J.J.P., Cnubben, N.H.P., Brand, W., Awad, H.M., Alink, G.M., Rietjens, I.M.C.M., van Beek, T.A., Fiamegos, Y.C., Beek, T.A., van, Jeurissen, S.M.F., Beek, T.A. van, Boersma, M.G., Sudhölter, E.J.R.   +12 more
core   +2 more sources

Estudo da adaptação da espécie Piper hispidinervum C. DC. (pimenta longa) à região do Vale do Itajaí - SC, através da composição química do óleo essencial obtido por hidrodestilação por micro-ondas e convencional Adaptation studies of Piper hispidinervum C. DC. (long pepper) species in Itajaí Valley - SC, by the chemical composition of essential oil obtained by microwave and traditional hydrodistillation

Acta Amazonica, 2011
Neste trabalho, a espécie Piper hispidinervum (pimenta longa), endêmica do estado do Acre, foi cultivada na região do Vale do Itajaí - SC, e sua adaptação foi avaliada em relação à composição química do óleo essencial obtido pelos processos de ...
Dilamara Riva, Edésio Luiz Simionatto, Alberto Wisniewski Jr, Airton Rodrigues Salerno, Terezinha Heck Schallenberger   +4 more
doaj   +1 more source

Determination and Optimisation of Descriptor Values of Safrole by Gas-Liquid Chromatographic Methods and Liquid-Liquid Partition Systems [PDF]

, 2019
In recent years, accumulation of harmful organic chemicals in various environmental and biological compartments causes regrettable harmful effects to humans and ecosystems.
Ambagaspitiya, A.W.T.D., Poole, C.F., Dayani, M.T., Ariyasena, J.A.T.C.   +3 more
core   +1 more source

Safrole Induces G0/G1 Phase Arrest via Inhibition of Cyclin E and Provokes Apoptosis through Endoplasmic Reticulum Stress and Mitochondrion-dependent Pathways in Human Leukemia HL-60 Cells

, 2012
[[abstract]]Safrole, a component of Piper betle inflorescence, is a carcinogen which has been demonstrated to induce apoptosis on human oral cancer HSC-3 cells in vitro and to inhibit HSC-3 cells in xenograft tumor cells in vivo.
闕甫伈;Chueh, Fu-Shin;鍾景光;Chung, Jing-Gung
core  

Physiologically based biokinetic (PBBK) model for safrole bioactivation and detoxification in rats

, 2011
A physiologically based biokinetic (PBBK) model for alkenylbenzene safrole in rats was developed using in vitro metabolic parameters determined using relevant tissue fractions.
van Bladeren, P.J., Khadka, D.B., Martati, E., Spenkelink, A., Boersma, M.G., Punt, A., Vervoort, J.J.M., Bladeren, P.J., van, Rietjens, I.   +8 more
core   +1 more source

Isomerização do óleo essencial de pimenta-longa (Piper hispidinervium C. DC) para a obtenção de isosafrol Isomerization of essential oil of (Piper hispidinervium) C. DC to obtain isosafrole

Acta Amazonica, 2010
As piperáceas brasileiras apresentam propriedades para serem utilizadas, entre outras aplicações, como inseticidas e antifúngicos. Dentre as piperáceas, pode-se citar a Piper hispidinervum C. DC.
Marco Aurelio Cremasco, Nazareno de Pina Braga   +1 more
doaj   +1 more source

The reaction of safrole derivatives with aluminum chloride: improved procedures for the preparation of catechols or their mono-O-Methylated Derivatives and a mechanistic interpretation

Journal of the Brazilian Chemical Society, 2001
An improved procedure for the "one-pot" preparation of cathecols from methylenedioxy-ring cleavage reaction of safrole derivatives with aluminum chloride is described.
Amorim Mauro B. de, Silva Alcides J. M. da, Costa Paulo R. R.   +2 more
doaj  

Malabaricone C-containing mace extract inhibits safrole bioactivation and DNA adduct formation both in vitro and in vivo

, 2014
Safrole, present in mace and its essential oils, causes liver tumors in rodents at high dose levels due to formation of a DNA reactive 1'-sulfooxysafrole.
Paini, A., van den Berg, J.H.J., van Bladeren, P.J., Boonpawa, R., Martati, E., Spenkelink, A., Berg, J.H.J., van den, Punt, A., Vervoort, J.J.M., Bladeren, P.J., van, Rietjens, I.   +10 more
core   +1 more source