Results 121 to 130 of about 328,017 (269)

Minimally Invasive Surgery for Adult Scoliosis: Recent Updates and Advancements. [PDF]

open access: yesCurr Rev Musculoskelet Med
Khan F   +4 more
europepmc   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Convergence on a Senescence‐Associated B Cell–MIF Signaling Axis in Joint Aging and Osteoarthritis Progression

open access: yesAdvanced Science, EarlyView.
Single‐cell and spatial transcriptomics implicate senescent B cells and macrophage migration inhibitory factor (MIF) signaling in aging and osteoarthritic joints. An injectable hydrogel combining quercetin with siRNA targeting MIF attenuates cartilage degeneration in a mouse model of osteoarthritis.
Weida Li   +11 more
wiley   +1 more source

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu   +5 more
wiley   +1 more source

Al1−xHfxN$\text{Al$_{1-x}$Hf$_{x}$N}$ Thin Films with Enhanced Piezoelectric Responses for GHz Surface Acoustic Wave Devices

open access: yesAdvanced Electronic Materials, EarlyView.
Reactively sputtered wurtzite Al1‐xHfxN thin films, exhibiting strong c‐axis texture and enhanced piezoelectric response, are demonstrated as a cost‐effective alternative to Al1‐xScxN. X‐ray absorption spectroscopy reveals that cross‐gap N 2p–Hf 5d hybridization increases the Born effective charge and enables a multifold increase in piezoelectric ...
Laura I. Wagner   +14 more
wiley   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

open access: yesAdvanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong   +5 more
wiley   +1 more source

A comprehensive analysis of the association of psychological profiling and sagittal balance parameters with neck pain in a non-deformity cervical spondylosis population: A prospective two-centers cross-sectional study. [PDF]

open access: yesNeurosurg Rev
Battistelli M   +12 more
europepmc   +1 more source

A High‐Precision Dynamic Movement Recognition Algorithm Using Multimodal Biological Signals for Human–Machine Interaction

open access: yesAdvanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This article describes a multimodal fusion data acquisition and processing system about electromyography for dynamic movement recognition and bioelectrical impedance for key posture recognition. In addition, a new dynamic–static fusion algorithm strategy is designed.
Chenhao Cao   +5 more
wiley   +1 more source

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