Results 91 to 100 of about 705,347 (360)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Saint-Maximin-la-Sainte-Baume – Boulevard Saint-Jean, Saint-Simon
ADLFI. Archéologie de la France - InformationsLe terrain concerné par le diagnostic, situé à 300 m au sud-est de la ville médiévale, est cependant assez éloigné du pôle central des découvertes, concentrées au nord-ouest de cette dernière. De ce fait, peu de vestiges sont connus aux alentours proches.Le terrain concerné par le projet occupe une superficie de 7 993 m2, dont environ 2 500 n’étaient ...
Monteil, Karine, Monteil, Karine
openaire +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Renaud Santerre (dir.), Pintendre 1900-2000. Un siècle d’histoire. Cap-Saint-Ignace, La Plume d’Oie, 2000, 652 p., tableaux, cartes, photos. [PDF]
, 2001 Paul Charest
openalex +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
KIRKLAR İNANCININ SOMUT İZLERİNE DAİR BAZI GÖZLEMLER
Türk Kültürü ve Hacı Bektaş Velî Araştırma DergisiThe expression “the saints of the unseen” in Sufism is used to refer to the three, seven and forty. Accordingly, Sufis have divided saints into different degrees and classes based on hadiths.
HAVVA YAZICI
doaj +1 more source