Results 91 to 100 of about 673,928 (344)

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Saint-Ukrainian Ivan (Maksymovych), Tobolsk Metropolitan, – the last saint canonized by the Russian Orthodox Church in the Synodal Epoch

open access: yesВолинський благовісник, 2018
The aggravation of church relations and the transition to a visible confrontation between the Ecumenical Constantinople and the Moscow Patriarchate (up to the termination of the Eucharistic communion) is due to the urgent issue for all Ukrainians - the ...
archpriest Vasyl Lozovytski
doaj   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

Житие Герасима Вощикова и традиции севернорусской агиографии

open access: yesВестник музыкальной науки, 2013
В статье анализируется житие старообрядческого подвижника Герасима Вощикова, составленное в начале XX в. северодвинским писателем Симеоном Гавриловым.
Першина, Мария Валерьевна
doaj   +1 more source

Saint Helen [PDF]

open access: yesArchaeological Journal, 1891
The Archaeological Journal, 48, 354 ...
openaire   +2 more sources

TRPM8 levels determine tumor vulnerability to channel agonists

open access: yesMolecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo   +18 more
wiley   +1 more source

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