Results 71 to 80 of about 317,520 (268)
Mélanges de la Casa de Velázquez, 2016 By looking for heroicness in biographical dictionaries we can place the hero, not as in isolated figure but as part of a larger pantheon that includes all the memorable figures who played a part in building the nation.
Jean-Pierre Dedieu
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Cardinal Karol Wojtyla’s Care about Adequate Celebration of St. Stanislaus’ Jubilee (1971 -1979)
Folia Historica Cracoviensia, 2003 “Polish Christian tradition linked two bishops and martyrs - witnesses, so to speak, of our Christening and Confirmation. From the point of view of the history of redemption - a spiritual process progressing through the history of a nation - it is still ...
Jan Szczepaniak
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Espacio, Tiempo y Forma. Serie II, Historia Antigua, 2016 En el presente artículo nos aproximamos a la investigación de la figura del hombre divino —θεῖος ἀνήρ— en la Antigüedad Tardía con el objeto de aportar un nuevo marco definitorio del mismo.
Marco Alviz Fernández
doaj +1 more source
ECOLOGICAL SAINTS: ADOPTING A GREEN GAZE OF THE LIFE AND WRITINGS OF SAINT MARGUERITE BOURGEOYS
Zygon, 2023 During this time of ecological crisis, spiritual guides are needed to provide inspiration and impel action. In the Roman Catholic tradition, saints act as role models and are associated with particular causes, locations, or professions.
doaj +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Dede Korkut Kitabı’ndaki Dumrul’un Delilikten Velîliğe Tekâmül Yolculuğu
Diyanet İlmi DergiTürk halk kültür ve inancına dair önemli bulgular taşıyan Deli Dumrul destanında tasavvufî açıdan birçok unsura rastlanmıştır. Temel tasavvufî kavramların temsil edildiği birçok sembol ve ifadenin destan içerisinde, bir sistem dâhilinde sonuca yönelik ...
Musa Kaval
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source