Results 71 to 80 of about 328,638 (269)
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Comparative Methods for Teaching Contemporary and Ancient Saints
ReligionsThis paper argues that a comparative study of saints is not only a useful classroom tool for historians and religionists, but an exceptionally powerful locus of pedagogical insight and cultural understanding.
Todd E. French, Mohammed Forero Bucheli
doaj +1 more source
Notas para un estudo dos refráns haxiocronolóxicos / Notes for a study of hagiochronological proverbs [PDF]
Cadernos de Fraseoloxía Galega, 2014 Este artigo estuda unha serie de refráns haxiocronolóxicos. Neles a referencia a un santo serve para marcar o tempo. Vése en que áreas culturais son comúns este tipo de paremias. Analízanse en primeiro lugar as súas características xerais tales como as
Mª Rosario Soto Arias
doaj
Folia Historica Cracoviensia, 2003 Priest Wtadysla'w Chotkowski, professor at the Faculty of Theology of the Jagiellonian University, was one of the most outstanding Polish preachers at the turn of the 20th century.
Jacek Urban
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source