Results 61 to 70 of about 317,520 (268)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
ARSTANBEK IS THE GREAT MASTER OF THE ART OF SPEECH [PDF]
Vestnik Issyk-Kulʹskogo universitetaThe article is about Arstanbek Buylash uulu, about his high creative power of personality, revealing his creative potential in the highest degree, about his creation of new, original, deep, incomparable works, about his discovery of those peaks, to which
Toktomatova G. O.
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Christian Feasts dedicated to Saints – an Interdisciplinary Perspective [PDF]
Annals of Philosophy, Social and Human Disciplines, 2012 Our paper is an interdisciplinary approach, of linguistic and theological analysis of a few lexemes that define saints who became popular in the Romanian culture and spirituality.
Carmen-Maria Bolocan
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The churches dedicated to Saint Bishop and Martyr Stanisław in Kraków, built in 20th century
Folia Historica Cracoviensia, 2003 1. Die Pfarrkirche Zum Hl Bischof und Märtyrer Stanislaus in Dąbie Dąbie liegt 3 Kilometer östlich vom Stadtzentrum entfernt. In die Stadt wurde es 1911 eingemeindet. In den Jahren 1965-75 entstand hier eine Wohnsiedlung.
Józef Szymon Wroński
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Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Oskar Arnulfo Romero, święty trudnego czasu
Studia Koszalińsko-Kołobrzeskie, 2020 The article, through the example of St. Oscar Romero, the archbishop of San Salvador in 1977–1980, shows that the sanctity is always embedded in the particular historical, geographical and spiritual reality – first part.
Witold Lesner
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source