Results 61 to 70 of about 328,638 (269)
A Note on the Balto-Slavic and Indo-European Background of the Proto-Slavic Adjective *svętъ ‘Holy’
Studia Ceranea, 2017 The standard etymological explanation of the Proto-Slavic adjective *svętъ ‘holy, saint’ – a word of extreme literary, cultural and religious importance in the Slavic world – concentrates on the formal match with Lithuanian šventas ‘id.’ and Avestan ...
Marek Majer
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
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Dede Korkut Kitabı’ndaki Dumrul’un Delilikten Velîliğe Tekâmül Yolculuğu
Diyanet İlmi DergiTürk halk kültür ve inancına dair önemli bulgular taşıyan Deli Dumrul destanında tasavvufî açıdan birçok unsura rastlanmıştır. Temel tasavvufî kavramların temsil edildiği birçok sembol ve ifadenin destan içerisinde, bir sistem dâhilinde sonuca yönelik ...
Musa Kaval
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
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VENERATING SHAYKH ABD AL-QADIR AL-JILANI IN INDONESIA AND TURKIYE
Journal of Indonesian IslamShaykh Abd al-Qadir al-Jilani is a prominent figure in Muslim society. Compared to the influence of his intellectual works, the revered status he has earned is in large part because of his known outstanding spiritual qualities. He enjoys a place of honor
Imam Ghazali Said +3 more
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
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Kabir and Pedagogy: Teaching the Politics of Religion through the Hagiography of an Indian Saint
ReligionsThis essay discusses the virtues of hagiology-driven teaching and the pedagogical value of the saint in the religious studies classroom, focusing on how a series of class assignments and activities centered on the Indian devotional saint Kabir function ...
Patton Burchett
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