Structural basis of secreted acid phosphatase polymerization in the Leishmania parasite
Abstract Enzymes that assemble into filaments typically transition between protomeric and polymeric states in response to cellular conditions. In contrast, the secreted acid phosphatase (SAP) of Leishmania, one of the most abundant extracellular glycoproteins produced by the parasite and regarded as a major virulence factor in the neglected tropical ...
Priyanka Bose +4 more
wiley +1 more source
Controlled Formation of Carbon Nanotubes and Nanotube Junctions from Bilayer Graphene
Twisted bilayer graphene is cut using a scanning transmission electron microscope to create individual chiral carbon nanotubes and interconnected nanotube junctions. The sculpting is facilitated by in situ heating and automated beam control. Bilayer graphene ribbons with a width of less than approximately 4 nm spontaneously convert to CNTs, while no ...
Michael Schlegel +3 more
wiley +1 more source
Proof-of-concept validation of noninvasive detection of cortical spreading depolarization with high-resolution direct current-electroencephalography with future device recommendations. [PDF]
Brown BR +6 more
europepmc +1 more source
A cryo‐EM processing pipeline for microtubules using CryoSPARC
Cryo‐EM reconstructions of microtubules are currently technically challenging and time‐consuming for average users. A cryo‐EM processing pipeline for microtubules using CryoSPARC has been developed that overcomes many of these current issues.Microtubules are cytoskeletal filaments that are typically characterized by a discontinuous helical lattice of α/
Daniel Zhang +7 more
wiley +1 more source
Considering brain state for individualized functional connectivity-based rTMS. [PDF]
Shearer H +3 more
europepmc +1 more source
Archives of impact: The politics of craters on Earth
This paper examines Earth’s 195 confirmed impact craters as archives, exploring their cataloguing and presentation as heritage sites. It argues Western scientific framings using military language and emphasising catastrophe overlook settler colonialism’s violent histories and marginalise indigenous earth‐sky cosmologies.
Gareth Hoskins
wiley +1 more source
Temporal patterns of adolescent screen time and compulsive internet use in Moroccan high school students. [PDF]
Imrani S, Touri B, Romo L, Zerhouni O.
europepmc +1 more source
Resilience to Cardiac Aging in Greenland Shark Somniosus microcephalus
Greenland shark Somniosus microcephalus shows severe cardiac aging such as fibrosis, lipofuscin buildup, mitochondrial damage, and oxidative stress, unseen in comparison species Etmopterus spinax and Nothobranchius furzeri, yet remain healthy. S. microcephalus resilience suggests unique mechanisms that preserve heart function for centuries, offering ...
Elena Chiavacci +14 more
wiley +1 more source
Label-free metabolic imaging and energy costs in Chlamydomonas. [PDF]
Boccara M +3 more
europepmc +1 more source

