Results 31 to 40 of about 1,520 (309)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Shaping Charisma: Muda Waly al-Khalidi and Saint-Making in Contemporary Indonesia

open access: yesMillati: Journal of Islamic Studies and Humanities
This article aims to clarify the social process of creating waliyullah in Muslim society. Waliyullah is often considered the highest prestige acquired by a mere human other than the Messenger.
Sehat Ihsan Shadiqin
doaj   +1 more source

Tasavvufa Yönelik Eleştiriler Bağlamında “Velâyet” Kavramının Kaynaklarda Ele Alınışı

open access: yesTasavvuf İlmi ve Akademik Araştırma Dergisi, 2021
Tasavvuf, tarih boyunca bir taraftan İslam’ın yayılmasında önemli görevler icra etmiş, diğer taraftan Müslümanların büyük kırılmalar yaşadığı dönemlerde, onları ümmet şuuru ile bir arada tutup yeniden toparlanmalarını sağlamıştır.
Mehmet Şirin Ayiş
doaj  

La confrérie noire de Baba Merzoug : la sainteté présumée et la fête de l’équilibre

open access: yesإنسانيات, 2006
In general, the black descendents of former slaves emphasize the fact that they descend from Sidi B’llel or his children. It’s generally admitted to be the name of the celebration under study.
Salim Khiat
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

The Cults of Holy Rulers in the Early Medieval Europe: The Interaction between Religious and Political Aspects [PDF]

open access: yesУченые записки Казанского университета: Серия Гуманитарные науки, 2016
In this paper, we have made an attempt to review the complex interaction between two spheres of consciousness, political and religious, based on various cults of the saint rulers.
N.Yu. Bikeeva, A.D. Mokropolova
doaj  

Santos e devotos no império ultramarino português

open access: yesReligião e Sociedade, 2009
O artigo faz uma história da coleção de vilancicos de São Gonçalo de Amarante, que integram a Coleção Barbosa Machado na Biblioteca Nacional do Rio de Janeiro e, simultaneamente, apresenta reflexões sobre a relação santo-devoto no Império Ultramarino ...
Beatriz Catão Cruz Santos
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

La falsa santità – il caso di Sibilla di Marsal

open access: yesSeminare, 2022
The object of this study is Sybilla of Marsal, a woman who lived in the 13th-century France. Her story was first described by Richer of Senones in Gesta Senoniensis Ecclesiae.
Anna Głusiuk
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

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