Results 41 to 50 of about 1,520 (309)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Analisa Sufistik Mimpi Nubuwwah dalam Proses Kenabian

open access: yesTeosofi: Jurnal Tasawuf dan Pemikiran Islam, 2015
This article tries to scrutinize dreams as prophetic command (nubuwwah) and happy news (mubashshirât) from Allah. The article describes the concept of prophethood, the concept of sainthood, the relation between prophethood and sainthood, and dreams as a ...
Lalu Agus Satriawan
doaj  

The Glorious Martyrdom of the Cross. The Franciscans and the Japanese Persecutions of 1597

open access: yesCulture & History Digital Journal, 2017
The Franciscan martyrdom of 1597 was not an unprecedented event in the young history of Japanese Christianity, as a first wave of persecutions occurred ten years earlier. But the echo it found in Asia, America and Europe, was unparalleled.
Hélène Vu Thanh
doaj   +1 more source

Źródła duchowości służebnicy Bożej Dorothy Day

open access: yesPolonia Sacra, 2022
The article presents the spirituality of Dorothy Day. It is a result of an analysis of her publications, that is books and articles in different magazines, above all “The Catholic Worker”.
Wojciech Zyzak
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Vicegerency of the Perfect man in Islamic mysticism [PDF]

open access: yesحکمت اسرا, 2009
The concept of vicegerency is a key concept in Islamic studies in general and in Islamic mysticism in particular. The present article deals with the concept of vicegerency in Islamic mystical sources comparing it with that in Islamic studies.
Asadullah Shukriyan
doaj  

Some Foundational Considerations on Taxonomy: A Case for Hagiography

open access: yesReligions, 2019
Since its now notorious mid-1800s historiographical positivist critiques, the term hagiography was often contested as a valid and valuable category for the comparative study of religious phenomena.
Massimo A. Rondolino
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Establishing Spiritual Authority in Female Visionary Writing: The Book of Margery Kempe

open access: yesReligions
The Book of Margery Kempe is an extraordinary work of female visionary writing, in which Margery Kempe narrates her intimate and direct communications with Jesus Christ.
Mengge Wang
doaj   +1 more source

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