Results 141 to 150 of about 279,940 (313)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Corrigendum to “SDHi fungicides: An example of mitotoxic pesticides targeting the succinate dehydrogenase complex” [Environ. Int. 180 (2023) 108219]

Environment International
Carolina Duarte Hospital, Arnaud Tête, Kloé Debizet, Jules Imler, Céline Tomkiewicz-Raulet, Etienne B. Blanc, Robert Barouki, Xavier Coumoul, Sylvie Bortoli   +8 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Medication Adherence and Its Determinants in Patients with Type 2 Diabetes Mellitus Attending an Internal Medicine Outpatient Department. [PDF]

Maedica (Bucur)
Olatunji OO, Patnaik PK, Sathiya V, Otu-Ansah JB, Mede BN.   +4 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Is Religious Coping a Protective Factor, and for Whom? A Moderation and Subgroup Analysis on Loneliness and Suicide Attempts Among LGBTQ+ Adults Raised as Latter-Day Saints. [PDF]

Suicide Life Threat Behav
Kim S, Lefevor GT, Miller CK, Jankowski PJ.   +3 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Keratinizing Squamous Cell Carcinoma Masquerading as Basal Cell Carcinoma Constituting a Diagnostic Pitfall: A Case Report With Etiopathogenetic Discourse and Mohs Micrographic Surgical Management. [PDF]

Cureus
Sanyal S, Andrew R, Graham-Durand D, Kotbagi S, Austrie B.   +4 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Paraneoplastic Arthritis Mimicking Late-Onset Rheumatoid Arthritis in an Older Smoker: A Diagnostic Challenge. [PDF]

Cureus
Swamy N, Saiprasad S, Garate D, Kway K.
europepmc   +1 more source