Results 141 to 150 of about 65,433 (290)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Case of Appendiceal Goblet Cell Adenocarcinoma With Gastric Metastasis. [PDF]

ACG Case Rep J
Gautam A, Jafferjee M, Nimmagadda K, Simien M, Cimo M.   +4 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Kaleidoscopes in the ICU. [PDF]

Palliat Support Care
Zieneldien T.
europepmc   +1 more source

Church of Jesus Christ of Latter Day Saints Church History dated February 23, 1856

, 2011
Mentions the origin of what was called the Tintic War with local Indians.
Church of Jesus Christ of Latter-day Saints
core  

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Ultrafast visual detection of Streptococcus suis via HtpsC‐targeted LAMP–CRISPR–Cas12a coupled with lateral flow immunochromatography

FEBS Open Bio, EarlyView.
A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li, Miao Xin, Xiao‐wen Cui, Shi‐yin Yu, Fei Meng, Min Cao, Xiao‐hui Xiong, Yi‐chen Lu   +7 more
wiley   +1 more source

Step-by-Step Femoral-Femoral Percutaneous Mechanical Aspiration Debulking of Anterior Tricuspid Valve Vegetation. [PDF]

JACC Case Rep
Amar MR, Kara R, Kantheti H, Ramarathnam V, Hamadeh A.   +4 more
europepmc   +1 more source

Saintes – Passage Saint-Julien

ADLFI. Archéologie de la France - Informations
Si les opérations en milieu urbain se sont multipliées à Saintes ces dernières années, celles-ci se sont déroulées hors de la ville remparée. À l’exception du rempart lui-même, fréquemment observé depuis le xviie s., aucune intervention intra muras n’a, jusque-là, été effectuée.
Buisson, Jean-François, Buisson, Jean-François   +1 more
openaire   +1 more source

Printing a New Saint: Woodcut Production and Canonization of Saints in Late Medieval Italy

, 2015
The essay analyzes a group of 15th century woodcuts depicting saints such as Bernardino of Siena, Nicholas of Tolentino, Catherine of Siena, suggesting that they were produced to promote the Saints' cult following their recent ...
COBIANCHI, Roberto
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