Results 31 to 40 of about 65,433 (290)

‘So great a cloud of witnesses’: Shaping Sacred Space in the Victorian Anglo-World

open access: yes19, 2020
This article explores one of the predominant themes in nineteenth-century stained glass: the urge to assemble collections of individual figures into genealogies of spiritual or institutional descent.
Gareth Atkins
doaj   +2 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Former All Saints Church in Jersey City

open access: yes, 2023
All Saints was built on the southwest corner of Pacific and Communipaw Avenue in 1910. It was designed by John T. Rowland in the Gothic Revival Style.Original file name All Saints Church in Jersey City Collage_Fotor_Fotor ...
Beards, Daniel E.
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Is it Possible to Successfully Combat Corruption by Scanning Old Rosaries?

open access: yesУправленческое консультирование, 2018
The article is dedicated to the International Day against Corruption, which is celebrated annually on December 9. Corruption as a complex socio-economic phenomenon is generated by a variety of reasons, most of which have already been identified and ...
A. N. Tsatsulin
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Modes and moods of “Slave Anastácia,” Afro-Brazilian saint

open access: yesJournal de la Société des Américanistes, 2018
Agency activated through exchanges with saints is not simply present or absent. Rather it is emergent, depending on the mode of saints’ material and social configurations, and the mood evoked by a specific saint’s manifestation.
Paul Christopher Johnson
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

NFL Governance and the Fate of the New Orleans Saints: Some Observations [PDF]

open access: yes
Prior to 2005, New Orleans had struggled to retain its NFL franchise. The Saints remained in the city, despite an outdated stadium and small media market, only through generous direct public subsidies to the team.
Robert Baade, Victor Matheson
core   +2 more sources

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