Results 41 to 50 of about 65,433 (290)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Acute compartment syndrome is a medical emergency caused by increased pressure within a closed fascial space, leading to tissue ischemia and potential limb loss or death if untreated.
Simar Goyal +6 more
doaj +1 more source
Road rehabilitation as an opportunity to analyse the approach in designing pavement constructions [PDF]
The pavement constructions of highways built in he eighties mainly featured low bearing surfaces with cement stabilization and asphalt layers with the total thickness of up to 26 cm.
Erjavec Slavoljub +2 more
doaj +1 more source
The Strange Cult of Queen Dagmar
In 1205, the Danish king Valdemar II married a Bohemian princess, known in her new country as Dagmar. Little contemporary information exists concerning this queen, who died only seven years after her arrival.
Tracey R. Sands
doaj +1 more source
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Tangible Traces 0f Devotion: The Post-mortem Life of Relics
Though relics have attracted immense interest from a variety of scholars, not much attention has been paid to the practical handling of the holy corporal remains.
Anna Kjellström
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
On reading the “Duino Elegies” by Rainer Maria Rilke
The article discusses the book Rycerz i śmierć written by Katarzyna Kuczyńska-Koschany. The book includes essays on Reiner Maria Rilke’s Duino Elegies published earlier that have been revised and updated.
Barbara Surowska
doaj +1 more source

