Results 191 to 200 of about 217,768 (295)

Models of Care in Hospital Medicine: An Analysis of Advance Practitioner Utilization Using Monte Carlo Methods. [PDF]

Perm J
Sharma R, Akram N, Madden M.
europepmc   +1 more source

The GLP1R Agonist Semaglutide Inhibits Reactive Astrocytes and Enhances the Efficacy of Neural Stem Cell Transplantation Therapy in Parkinson's Disease Mice

Advanced Science, EarlyView.
Compared to transplantation of neural stem cells (NSCs) alone, the combined treatment of NSCs with semaglutide more effectively improves motor dysfunction in Parkinson's disease (PD) mice. This synergistic effect may result from semaglutide's ability to suppress microglial activation, thereby preventing the transformation of resting astrocytes into ...
Dan Song, Xiaoya Zou, Di Ma, Yuying Zhao, Tingting Liu, Bibiao Shen, Oumei Cheng   +6 more
wiley   +1 more source

A cross-sectional survey of community health workers and their roles in Indiana. [PDF]

BMC Health Serv Res
Scanlon M, Thomas MR, Tang Q, Gonzalvo JD, Ruiz Y, Hart M, Jackson J, Litzelman DK.   +7 more
europepmc   +1 more source

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Factors influencing retention of patient-facing genetic counselors: Role of generational age and work environment. [PDF]

J Genet Couns
Frye JR, Wetherill L, Cohen SA, Fitzgerald-Butt SM, Helm BM, Prucka SK, Schroeder CD.   +6 more
europepmc   +1 more source

MTCH2 Deficiency Promotes E2F4/TFRC‐Mediated Ferroptosis and Sensitizes Colorectal Cancer Liver Metastasis to Sorafenib

Advanced Science, EarlyView.
This study identifies MTCH2 as a crucial regulator of ferroptosis in colorectal cancer (CRC) progression. High expression of MTCH2 is correlated with poor prognosis in CRC patients. Furthermore, MTCH2 depletion induces ferroptosis to suppress CRC liver metastasis via the E2F4/TFRC axis and sensitizes tumors to sorafenib treatment, supporting MTCH2 as a
Pu Xing, Jiangbo Chen, Hao Hao, Xiaowen Qiao, Xinying Yang, Kai Weng, Jie Chen, Lin Song, Tianqi Liu, Yifan Hou, Tongkun Song, Yumeng Ran, Bo Chen, Hong Yang, Wei Zhao, Zaozao Wang, Jiabo Di, Beihai Jiang, Xiangqian Su   +18 more
wiley   +1 more source

The financial challenges of caring for children with profound intellectual disability as experienced by newly qualified nurses. [PDF]

BMC Nurs
Molefe L.
europepmc   +1 more source

Identifying Myeloid‐Derived Suppressor Cells and Lipocalin‐2 as Therapeutic Targets for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang, Haoyun Li, Hongfei Wang, Liangyu Shi, Ying Shing Chan, Yu Wang, Graham Ka Hon Shea   +6 more
wiley   +1 more source

Physician Employment in America: Private Practices Dominate Despite Increased Hospital Employment. [PDF]

JSLS
Popover JL, Jones T, Kalathia C, Mackey A, King N, Sardzinski E, Oulton Z, Imam A, Al-Masri M, Toomey PG.   +9 more
europepmc   +1 more source

Irisin‐Loaded Cerium‐Containing Mesoporous Bioactive Glass for Effective Immunomodulation and Odontogenesis of Dental Pulp Cells

Advanced Science, EarlyView.
The Irisin/Ce‐MBGNs delivery system can slowly release myokine Irisin for vital pulp therapy. Irisin/Ce‐MBGNs can enhance mitochondrial function and promote the differentiation of inflammatory macrophages toward M2‐Mφ, thereby regulating the immune response mechanism of inflamed dental pulp.
Mingxin Wang, Yuxin Yang, Jingyao Guo, Yan Chen, Xiaolin Lu, Guangdong Zhang, Yuli Wang, Minhui Yao, Yue Liu, Qian Ma   +9 more
wiley   +1 more source