Results 101 to 110 of about 4,939,141 (238)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Unsupervised salient object detection with pseudo-labels refinement [PDF]

In Salient Object Detection (SOD), most methods rely on manually annotated labels, which are costly. As a result, unsupervised methods have gained significant attention.
Liu, H., Zheng, Y., Wang, Pengjie, Yang, Xiaosong   +3 more
core   +1 more source

Are All Pixels Equally Important? Towards Multi-Level Salient Object Detection [PDF]

, 2015
When we look at our environment, we primarily pay attention to visually distinctive objects. We refer to these objects as visually important or salient. Our visual system dedicates most of its processing resources to analyzing these salient objects.
Yildirim, Gökhan
core   +2 more sources

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Salient Object Detection Based on Feature Attention Purification [PDF]

Jisuanji kexue
In recent years,salient object detection technology has made great progress,and how to select and effectively integrate multi-scale features plays an important role.Aiming at the information redundancy problem that may be caused by existing feature ...
BAI Xuefei, SHEN Wucheng, WANG Wenjian
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Visual Saliency Detection Based on Global Guidance Map and Background Attention

IEEE Access
In the field of Visual Saliency Detection, accurately segmenting salient objects from images is crucial for various applications such as image editing and visual tracking.
Yanbin Peng, Mingkun Feng, Zhinian Zhai
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Salient Object Detection Based on Background Feature Clustering

Advances in Multimedia, 2017
Automatic estimation of salient object without any prior knowledge tends to greatly enhance many computer vision tasks. This paper proposes a novel bottom-up based framework for salient object detection by first modeling background and then separating ...
Kan Huang, Yong Zhang, Bo Lv, Yongbiao Shi   +3 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source