Results 91 to 100 of about 4,939,141 (238)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Preprocessing for content-based image retrieval

, 2009
The research focuses on image retrieval problems where the query is formed as an image of a specific object of interest. The broad aim is to investigate pre-processing for retrieval of images of objects when an example image containing the object is ...
Rodhetbhai, Wasara
core   +1 more source

Robust Salient Object Detection and Segmentation [PDF]

, 2015
Background prior has been widely used in many salient object detection models with promising results. These methods assume that the image boundary is all background. Then, color feature based methods are used to extract the salient object. However, such assumption may be inaccurate when the salient object is partially cropped by the image boundary ...
Hong Li, Wen Wu 0001, Enhua Wu
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Uncertainty-aware Joint Salient Object and Camouflaged Object Detection

Visual salient object detection (SOD) aims at finding the salient object(s) that attract human attention, while camouflaged object detection (COD) on the contrary intends to discover the camouflaged object(s) that hidden in the surrounding. In this paper,
Zhang, Jing, Dai, Yuchao, Li, Aixuan, Zhang, Tong, Liu, Bowen, Lv, Yunqiu   +5 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Evaluation of an Algorithm for the Automatic Detection of Salient Frequencies in Individual tracks of Multi-track Musical Recording [PDF]

, 2015
This paper evaluates the performance of a salient frequency detection algorithm. The algorithm calculates each FFT bin maximum as the maximum value of that bin across an audio region and identifies the FFT bin maximum peaks with the highest five deemed ...
Wakefield, Jonathan P., Dewey, Christopher   +1 more
core   +1 more source

Tensor Decomposition for Salient Object Detection in Images

Big Data and Cognitive Computing, 2019
The fundamental challenge of salient object detection is to find the decision boundary that separates the salient object from the background. Low-rank recovery models address this challenge by decomposing an image or image feature-based matrix into a low-
Junxiu Zhou, Yangyang Tao, Xian Liu
doaj   +1 more source