Results 71 to 80 of about 4,939,141 (238)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Salient Object Detection via Recursive Sparse Representation

Remote Sensing, 2018
Object-level saliency detection is an attractive research field which is useful for many content-based computer vision and remote-sensing tasks. This paper introduces an efficient unsupervised approach to salient object detection from the perspective of ...
Yongjun Zhang, Xiang Wang, Xunwei Xie, Yansheng Li   +3 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Salient object detection with adversarial training

IET Image Processing, 2019
The generative adversarial network has been shown to produce state‐of‐the‐art results of image generation. In this study, the authors propose a novel adversarial training method to train salient object detection (SOD) models. They train a convolutional SOD network along with a gated adversarial network that discriminates salient maps coming either from
Zhijie Wang 0010, Wei Zhang 0021, Xuewen Rong, Yibin Li 0001   +3 more
openaire   +2 more sources

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Selective feature fusion network for salient object detection

IET Computer Vision, 2023
Fully convolutional neural networks have achieved great success in salient object detection, in which the effective use of multi‐layer features plays a critical role. Based on this advantage, many saliency detectors have emerged in recent years, and most
Fengming Sun, Xia Yuan, Chunxia Zhao
doaj   +1 more source

RCNet: Related Context-Driven Network with Hierarchical Attention for Salient Object Detection

Recent progress in salient object detection (SOD) mainly depends on dilated convolution with different receptive fields to capture contextual information for multi-scale learning.
Kuan-Ching Li, Yanguang Sun, Zhang, Ji, Bo Jiang, Jiang, Bo, Hanling Zhang, Bin Ge, Ji Zhang, Xia, Chenxing, Zhang, Hanling, Li, Kuan-Ching, Ge, Bin, Chenxing Xia, Sun, Yanguang   +13 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source