Results 91 to 100 of about 2,292,309 (282)

Extent and mechanism of sealing in transected giant axons of squid and earthworms [PDF]

, 1994
Transected axons are often assumed to seal at their cut ends by the formation of continuous membrane barriers that allow for the restoration of function in the axonal stumps.
Ballinger, Martis L., Bittner, George D., Fishman, Harvey M., Krause, Todd L.   +3 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Oral, nasal and pharyngeal exposure to lipopolysaccharide causes a fetal inflammatory response in sheep. [PDF]

, 2015
BackgroundA fetal inflammatory response (FIR) in sheep can be induced by intraamniotic or selective exposure of the fetal lung or gut to lipopolysaccharide (LPS).
Jobe, Alan H, Kallapur, Suhas G, Kannan, Paranthaman Senthamarai, Kemp, Matthew W, Kramer, Boris W, Maneenil, Gunlawadee, Newnham, John P, Saito, Masatoshi   +7 more
core   +3 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Participation of interleukin-5, interleukin-8 and leukotriene B4 in eosinophil accumulation in two different experimental models

Memorias do Instituto Oswaldo Cruz, 1997
There are several experimental models describing in vivo eosinophil (EO) migration, including ip injection of a large volume of saline (SAL) or Sephadex beads (SEP).
Sandra HP Oliveira, Lúcia H Faccioli, Sérgio H Ferreira, Fernando Q Cunha   +3 more
doaj   +1 more source

Saline Conversion and Ice Structures from Artificially Grown Sea Ice [PDF]

, 1967
The environment of cold regions is generally viewed as inhospitable, primarily due to application of ideal processes and techniques suitable to temperate zones. The work herein is a step toward solving two environmental problems.
Behlke, C. E., Johnson, P. R., Peyton, H. R.   +2 more
core  

Modeling electrodialysis and a photochemical process for their integration in saline wastewater treatment. [PDF]

, 2010
Oxidation processes can be used to treat industrial wastewater containing non-biodegradable organic compounds. However, the presence of dissolved salts may inhibit or retard the treatment process. In this study, wastewater desalination by electrodialysis
Borges F., De Aguiar P. F., Esplugas S., Gob S., Gogate P. R., Maciel R., Peretti M. T., Pignatello J. J., Strathmann H.   +8 more
core   +3 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Geotouristic Product – Saline Solutions of Dębieńsko / Geoturistický Produkt - Solné Roztoky Z Debienska

GeoScience Engineering, 2011
Rozvojovými příležitostmi pro post-těžební oblasti by mohly být nové směry podnikání, a rovněž nový přístup k místním přírodní zdrojům. Článek se zabývá charakteristikou solanky vyráběné v podniku odsolení důlních vod „Dębieńsko“ v Czerwionka-Leszczynyna
Tobór-Osadnik Katarzyna, Wyganowska Małgorzata   +1 more
doaj   +1 more source