Results 111 to 120 of about 3,024,565 (379)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
De Novo Transcriptional Analysis of Alfalfa in Response to Saline-Alkaline Stress
Frontiers in Plant Science, 2016 Saline-alkaline stress, caused by high levels of harmful carbonate salts and high soil pH, is a major abiotic stress that affects crop productivity. Alfalfa is a widely cultivated perennial forage legume with some tolerance to biotic and abiotic stresses,
Yimin An +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Assessment of lithium ingestion on cognition and some subset of motor skill
Journal of Pharmacy and Bioallied Sciences, 2010 Background : Patients taking lithium often report of difficulties in concentration, memory, learning, and attention. Laboratory tests of cognitive functions in healthy volunteers on chronic lithium demonstrate that disruptions in memory-learning ...
P D Shallie +4 more
doaj +1 more source
BENEFITS OF CONTROLLING SALINE WATER IN COLORADO [PDF]
The Arkansas River in Colorado is confronted with a salinity issue; the majority of this salinity problem is due to agricultural runoff caused by irrigation.
Ellingson, Lindsey +3 more
core +1 more source
Behavioural effects of hypersaline exposure on the lobster Homarus gammarus (L) and the crab Cancer pagurus (L) [PDF]
, 2014 There is scarce existing information in the literature regarding the responses of any marine species, especially commercially valuable decapod crustaceans, to hypersalinity.
Elliott, Michael +2 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Journal of Pharmacy and Bioallied Sciences, 2017 Background and Objectives: Two of the most critical factors affecting the prognosis of an avulsed tooth after replantation are extraoral dry time and the storage media in which the tooth is placed before treatment is rendered.
Vivian Flourish D′Costa +4 more
doaj +1 more source
Microwave Heating of Water, Ice and Saline Solution: Molecular Dynamics Study
, 2006 In order to study the heating process of water by the microwaves of 2.5-20GHz frequencies, we have performed molecular dynamics simulations by adopting a non-polarized water model that have fixed point charges on rigid-body molecules.
Havriliak S. +4 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source