Results 111 to 120 of about 2,900,627 (391)
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
An assessment of wheat (Triticum aestivum L.) genotypes under saline and waterlogged compacted soil conditions, I: grain yield and yield components [PDF]
, 2013 A pot experiment was conducted to study effects of salinity and waterlogging under soil compaction conditions on grain yield and yield components of wheat. Treatments were arranged in a factorial layout assigned to a randomized complete design with three
Asgari, Hamid +2 more
core +1 more source
De Novo Transcriptional Analysis of Alfalfa in Response to Saline-Alkaline Stress
Frontiers in Plant Science, 2016 Saline-alkaline stress, caused by high levels of harmful carbonate salts and high soil pH, is a major abiotic stress that affects crop productivity. Alfalfa is a widely cultivated perennial forage legume with some tolerance to biotic and abiotic stresses,
Yimin An +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
THE STUDY OF ADAPTATION OF THE METALIC TOWER IN ORDER TO MAKE TWO EMBARKING RAMPS FOR THE TOURISTS AT THE UNIREA SHAFT FROM THE SLĂNIC PRAHOVA SALINE [PDF]
Analele Universităţii "Constantin Brâncuşi" din Târgu Jiu: Seria Inginerie, 2019 In this paper, we show the solution for the realisation of two ramps for embarking tourists starting from the construction of the cage with two storeys,wich doubles the transportation capacity for the Unirea shaft at the SlănicPrahova Saline, in order to
Iosif Dumitrescu, Vilhelm Itu
doaj
Journal of Orthopaedic Translation, 2017 In vitro and in vivo studies evidenced that mesenchymal stem cells (MSCs) contribute to intervertebral disc (IVD) regeneration by differentiation towards the disc phenotype and matrix synthesis and/or by paracrine signalling to endogenous cells, thereby ...
Marianna Peroglio +6 more
doaj +1 more source
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Effect of a poloxamer 407-based thermosensitive gel on minimization of thermal injury to diaphragm during microwave ablation of the liver. [PDF]
, 2017 AIM: To assess the insulating effect of a poloxamer 407 (P407)-based gel during microwave ablation of liver adjacent to the diaphragm. METHODS: We prepared serial dilutions of P407, and 22.5% (w/w) concentration was identified as suitable for ablation ...
Dou, Rui +7 more
core +2 more sources
Groundwater Salinization in France
Procedia Earth and Planetary Science, 2013 AbstractThe state, sources, and vectors of salinity in French aquifers are assessed through a GIS-based approach and a literature review of geochemical studies. Seawater intrusion is dominant in the insular context, but the most impacted water bodies are inland aquifers affected by WRI with Permian to Tertiary evaporites, mixing with primary and ...
Kloppmann, W. +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source