Results 31 to 40 of about 1,702,356 (260)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Office of Saline Water Reports

open access: yes, 1965
Report issued by the Office of Saline Water over studies on seawater degasification with a focus on desorption of oxygen and carbon dioxide. The results are presented and discussed.
M. W. Kellogg Company
core   +2 more sources

ROS homeostasis and cell wall biosynthesis pathway are involved in female inflorescence development of birch (Betula platyphylla)

open access: yesBMC Plant Biology
Background Female inflorescence development from megasporogenesis to gametogenesis, and mature female gametophyte (FG), is a complex and important event in plant sexual reproduction. However, how this essential developmental process is regulated in birch
Mengjie Cai   +9 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Comparison of local anaesthetic versus saline erector spinae plane block for perioperative opioid consumption and postoperative pain in open posterior spine surgeries - A randomised controlled trial

open access: yesIndian Journal of Anaesthesia
Background and Aims: Postoperative pain is common after spine surgeries. Studies involving lumbar surgeries noted that erector spinae plane block (ESPB) decreased postoperative pain and opioid consumption.
Musunuru Mahendranath   +4 more
doaj   +1 more source

Mathematical modeling of formation of nanocrystalline calcium oxalate under physiological conditions

open access: yesФизико-химические аспекты изучения кластеров, наноструктур и наноматериалов, 2023
For the first time, a physicochemical model of the formation of poorly soluble compounds in the kidney nephron was developed on the basis of a mathematical description of the ideal displacement reactor.
O.A. Golovanova, V.M. Kiselev
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Efficacy of saline solutions of different osmotic pressures for hemorrhagic shock rats exposure to seawater immersion

open access: yesDi-san junyi daxue xuebao, 2020
Objective To investigate the effect of saline solutions of different osmotic pressures on the lethal triad, liver and kidney functions, and survival in hemorrhagic shock rats combined with seawater immersion.
ZHU Yu   +6 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

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