Results 61 to 70 of about 1,702,356 (260)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Effective therapy for periprosthetic joint infection through sequential application of non-contact low-frequency ultrasonic debridement and antiseptic solutions

Bone & Joint Research
Aims: Conventional mechanical debridement may be insufficient to fully eradicate biofilms adherent to prosthetic and surrounding tissue surfaces in cases of periprosthetic joint infection (PJI).
Fei Wang, Yicheng Li, Boyong Xu, Xiaogang Zhang, Wenbo Mu, Wentao Guo, Abudousaimi Aimaiti, Tuerhongjiang Wahafu, Dewen Xue, Yichang Li, Baochao Ji, Li Cao   +11 more
doaj   +1 more source

Viruses of Polar Aquatic Environments

Viruses, 2019
The poles constitute 14% of the Earth’s biosphere: The aquatic Arctic surrounded by land in the north, and the frozen Antarctic continent surrounded by the Southern Ocean.
Sheree Yau, Mansha Seth-Pasricha
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Laboratory evaluation of use of algae in saline water conversion : phase I final report.

, 1961
A two-part report on saline water conversion, calculating a survey of mechanisms of sodium and chloride ion transport and the design of experiments for application to demineralizing saline waters and laboratory evaluation of the use of algae in saline ...

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Efficacy of saline or salt-based solution mouthrinse in improving periodontal health: a systematic review

Brazilian Dental Science
Saline and salt-based solution mouthrinses have emerged as potential alternatives to chemical antiseptics like chlorhexidine. Due to their osmotic, antimicrobial, and tissue-healing properties, these solutions may provide measurable benefits in managing
Citra Jasmin Cangara, Sri Oktawati, Hasanuddin Thahir, Dian Setiawati, Sitti Raodah Juanita Ramadhan, Andi Nurul Ilmi Gunawan   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Saline-Water Resources of North Dakota [PDF]

, 1958
A description of the principal saline-water aquifers and surface-water bodies, with available ...
Langford, R. H., Robinove, C. J.
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Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Saline Regular Baptist Association [PDF]

Saline Regular Baptist Association was organized in 1836 at Spring Creek Church near Benton, Saline County. Churches represented were Spring Creek, Saline, and Union, of Saline County; Mount Gilead of Hot Spring County; Mount Bethel of Clark County; and ...
Saline Regular Baptist Association,
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