Results 51 to 60 of about 6,300,015 (283)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Impact of hydrodynamic conditions on optimum power generation in dual stage pressure retarded osmosis using spiral-wound membrane

Energy Nexus, 2022
The Dual Stage Pressure Retarded Osmosis technique is considered for power generation. The influence of feed flow rates, hydraulic pressure, and pressure drop on mass transfer and solute diffusion in a full-scale membrane model was investigated for the ...
Nahawand AlZainati, Sudesh Yadav, Ali Altaee, Senthilmurugan Subbiah, Syed Javaid Zaidi, John Zhou, Raed A. Al-Juboori, Yingxue Chen, Mohammad Hasan Shaheed   +8 more
doaj   +1 more source

A nanofluidic exchanger for harvesting saline gradient energy

Lab on a Chip
Optimising, by tailored flows, the coupled ion transport in the proximity of selective nanopores multiplies by 300 the recovered osmotic power.
Sripriya, Saranath, Picard, Cyril, Larrey, Vincent, Fournel, Frank, Charlaix, Elisabeth   +4 more
openaire   +4 more sources

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Transdermal iontophoresis patch with reverse electrodialysis

Drug Delivery, 2017
Reverse electrodialysis (RED) technology generates energy from the salinity gradient by contacting waters with different salinity. Herein, we develop the disposable skin patch using this eco-friendly energy.
Joon Lee, Kilsung Kwon, Minyoung Kim, Joonhong Min, Nathaniel S. Hwang, Won-serk Kim   +5 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Characteristics and Driving Mechanisms of Salinity Stratification during the Wet Season in the Pearl River Estuary, China

Journal of Marine Science and Engineering, 2022
In an estuary, stratification processes play a major role in inhibiting estuarine circulation, sediment transport, and the estuarine ecosystem. A detailed examination of the salinity stratification through the gradient Richardson number and the potential
Fang Yang, Xiaomei Ji, Wei Zhang, Huazhi Zou, Wenzhi Jiang, Yanwen Xu   +5 more
doaj   +1 more source

Blue energy: electricity production from salinity gradients by reverse electrodialysis [PDF]

, 2009
Energie opwekken op grote schaal uit het mengen van zoet en zout water is technisch en praktisch mogelijk. Wereldwijd is de potentie van deze schone energie – ‘blauwe stroom’ – zeer groot.
Post, J.W.
core  

Characterization of Membranes for Membrane-Based Salinity-Gradient Processes

, 2018
Pressure retarded osmosis (PRO) is one of the alternative applications for harvesting renewable energy by a natural phenomenon. As a particular free energy, the salinity gradient energy (SGE) from saline solutions with different concentrations has ...
Lim, S, Sungil Lim, Shon, H, Ho K. Shon
core   +1 more source