Results 221 to 230 of about 7,573 (281)

Osmotolerance is a driver of microbial carbon processes in the Elbe estuary. [PDF]

mSystems
Tobias-Hünefeldt SP, Woodhouse JN, Ruscheweyh H-J, Sunagawa S, Russnak V, Streit WR, Grossart H-P.   +6 more
europepmc   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Stoichiometry and Homeostasis of Sodium and Potassium Underpins Growth Adaptation of <i>Suaeda salsa</i> in the Yellow River Delta Wetland. [PDF]

Ecol Evol
Dongjie Z, Kaipeng Z, Jingyu Y, Xuepeng L, Lichao Z, Wenjun H, Mingye Z.   +6 more
europepmc   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Design Strategies and Roles of Hydrogels for Sustainable Energy Conversion and Harvesting from Natural and Biological Environments. [PDF]

Adv Mater
Lu W, Ong WL, Pan X, Li Z, Tian G, Ho GW.   +5 more
europepmc   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Circular economy through integrated industrial ecology: Innovations in resource recovery and process re-design. [PDF]

Biotechnol Notes
Geetha R.
europepmc   +1 more source

De Novo Design of Membrane‐Targeting Antimicrobial Peptides Against Gram‐Negative Bacteria Using a Generative Artificial Intelligence Framework

Advanced Science, EarlyView.
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu, Da‐Wen Sun, QingYi Wei, Yibing Zhang, Jidong Tang, Hongbin Pu   +5 more
wiley   +1 more source

Ocean stratification and tides control basal melting at the Ross Ice Shelf Grounding Zone. [PDF]

Sci Adv
Stevens CL, Stewart CL, Robinson NJ, Washam P, Horgan HJ, Lawrence JD, de Joux P, Schmidt BE, Hulbe CL, Dunbar GB.   +9 more
europepmc   +1 more source

Advances in Electromembrane Processes for Resource Recovery. [PDF]

Membranes (Basel)
Mitko K, Turek M, Reig M, Vecino X.
europepmc   +1 more source