Results 71 to 80 of about 5,144,139 (259)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Attenuation of salinity-induced stress and improvement of brackish water aquaculture of Labeo rohita through dietary interventions of multi-species probiotics

Applied Water Science
The present investigation was targeted to determine the attenuating role of multi-species probiotics (MSP) of Bacillus subtilis (1.9 × 1010 CFU/g), Bacillus licheniformis (2 × 1010 CFU/g), and Clostridium butyricum (2.2 × 108 CFU/g), against salinity ...
Habiba Jamil, Abdul Ghaffar, Fozia Afzal, Hussain Ahmad, Ghulam Abbas, Dalia Fouad, Farid Shokry Ataya, Kun Li   +7 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

High throughput sequencing of RNA transcriptomes in Ruditapes philippinarum identifies genes involved in osmotic stress response

Scientific Reports, 2017
Ruditapes philippinarum, is an economically important marine bivalve species. The ability to cope with low salinity stress is quite important for the survival of aquatic species under natural conditions. In this study, the transcriptional response of the
Hongtao Nie, Liwen Jiang, Peng Chen, Zhongming Huo, Feng Yang, Xiwu Yan   +5 more
doaj   +1 more source

Simple and efficient way to detect small polymorphic bands in plants

Genomics Data, 2015
There are many ways to detect polymorphism. In this study we use the microsatellite markers to detect the polymorphism for the salt tolerance. This method has been successfully conducted in Oryza sativa and Brassica juncea.
Manu Kumar, Seong Ryong Kim, Prabodh Chander Sharma, Ashwani Pareek   +3 more
doaj   +1 more source

Cerium oxide nanoparticles (CeO2-NPs) improve growth parameters and antioxidant defense system in Moldavian Balm (Dracocephalum moldavica L.) under salinity stress

, 2021
Salinity stress is of the most destructive stress factors causing adverse impacts on growth and productivity of crops plants. In order to combat or to make crop plants compatible with salinity stress, many attempts have been made to alleviate the ...
M. Mohammadi, Sima Panahirad, Anahita Navai, M. Bahrami, M. Kulak, Gholamreza Gohari   +5 more
semanticscholar   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

The photoprotective role of spermidine in tomato seedlings under salinity-alkalinity stress. [PDF]

PLoS ONE, 2014
Polyamines are small, ubiquitous, nitrogenous compounds that scavenge reactive oxygen species and stabilize the structure and function of the photosynthetic apparatus in response to abiotic stresses.
Lipan Hu, Lixia Xiang, Li Zhang, Xiaoting Zhou, Zhirong Zou, Xiaohui Hu   +5 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source