Results 81 to 90 of about 247,425 (305)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Plant Growth Promotion and Biocontrol of Pythium ultimum by Saline Tolerant Trichoderma Isolates under Salinity Stress [PDF]

, 2019
This present study evaluates three isolates of Trichoderma as plant growth promoting or biological control agents: Trichoderma aggressivum f. sp. europaeum, Trichoderma saturnisporum, and the marine isolate obtained from Posidonia oceanica, Trichoderma ...
Diánez Martínez, Fernando José, Gea Alegría, Francisco José, Moreno Gavira, Alejandro, Santos Hernández, Milagrosa, Sánchez Montesinos, Brenda   +4 more
core   +1 more source

Stomatal abundance and distribution in Prosopis strombulifera plants growing under different Iso-Osmotic salt [PDF]

, 2013
Changes in several environmental parameters are thought to affect stomatal development. Under salt stress, plants can regulate their transpiration flux through a better control of the stomatal opening (as a short-term response) and through modifications ...
Llanes, Analia Susana, Luna, Maria Virginia, Reginato, Mariana Andrea, Reinoso, Herminda Elmira   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Effect of alternating salinity stress on the gut microbiota of razor clam Sinonovacula constricta

Frontiers in Marine Science
IntroductionRazor clam (Sinonovacula constricta) is a bivalve of economic importance that widely resides in coastal and estuarine areas where salinity fluctuates rapidly.
Yi Yuan, Qunqun Jiang, Qinggang Xue, Qinggang Xue, Zhihua Lin, Zhihua Lin, Wenfang Dai, Wenfang Dai   +7 more
doaj   +1 more source

Evaluation of barley (Hordeum vulgare L.) genotypes for salinity tolerance under field conditions using the stress indices

Ain Shams Engineering Journal, 2018
Developing a suitable method for properly screening barley tolerance under salt stress is of great significance. Barley (an excellent model for the prediction of crop response to climate change) salt tolerance was investigated using stress tolerance ...
A. Jamshidi, H.R. Javanmard
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Low salinity stress increases the risk of Vibrio parahaemolyticus infection and gut microbiota dysbiosis in Pacific white shrimp

BMC Microbiology
Background Extreme precipitation events often cause sudden drops in salinity, leading to disease outbreaks in shrimp aquaculture. Evidence suggests that environmental stress increases animal host susceptibility to pathogens.
Yi-Ting Chang, Wan-Ting Huang, Ping-Lun Wu, Ramya Kumar, Han-Ching Wang, Hsiao-Pei Lu   +5 more
doaj   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Transcription factors-golden keys to modulate the plant metabolism to develop salinity tolerance

Plant Stress
Abiotic stressors such as drought, low temperature, heavy metals, waterlogging, nutrient imbalance, and salinity are major factors that affect the growth and development of crop plants, which, in turn, results in severe loss in production and yield of ...
Basharat Ahmad Bhat, Rakeeb Ahmad Mir, Wajahat Rashid Mir, Syed Suhail Hamdani, Manzoor Ahmad Mir   +4 more
doaj   +1 more source