Results 41 to 50 of about 43,636 (257)

A Novel Experimental Approach for In Vivo Analyses of the Salivary Gland Microvasculature

Frontiers in Immunology, 2021
Microvascular dysfunction plays a fundamental role in the pathogenesis of salivary gland disorders. Restoring and preserving microvascular integrity might therefore represent a promising strategy for the treatment of these pathologies.
Bernd Uhl, Bernd Uhl, Constanze Braun, Julian Dominik, Joshua Luft, Martin Canis, Christoph A. Reichel, Christoph A. Reichel   +7 more
doaj   +1 more source

Electrically Readable Lateral Flow Assay Using Organic Transistors for Diagnostic Applications

Advanced Materials, EarlyView.
Electrolyte‐gated organic field‐effect transistors (EGOFETs) are integrated with lateral flow (LF) paper fluidics to create a reusable, portable, and low‐cost point‐of‐care (PoC) diagnostic test. The devices are validated for Human Immunoglobulin G detection, achieving high sensitivity (0.1 fm), selectivity, and reproducibility with rapid results in 20–
María Jesús Ortiz‐Aguayo, Carme Martínez‐Domingo, Diego Gutiérrez, Dean Kos, Marta Mas‐Torrent   +4 more
wiley   +1 more source

Electroactive 3D Porous Graphene Foam Impedimetric Biosensor for Ultrasensitive Detection of MCF‐7‐Cells‐Derived Extracellular Vesicles in Human Serum

Advanced Materials Technologies, EarlyView.
A label‐free impedimetric biosensor based on electroactive 3D porous graphene foam enables ultrasensitive and selective detection of CD81 protein and MCF‐7 cell‐derived extracellular vesicles in human serum. Detection limits of 0.048 fg/mL for CD81 and ∼24 EVs/mL are achieved, demonstrating a robust platform for selective, label‐free, and ...
Michael Robert Furness, Ashish Kalkal, Tia Wardlaw, Jessica Valli, Suresh Chandra Baral, Pablo Lozano Sanchez, Marco Caffio, Sudhagar Pitchaimuthu, Olga Oikonomidou, Jason Webber, Nick R. Leslie, Anitha Devadoss   +11 more
wiley   +1 more source

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

Regenerating Gene Protein as a Novel Autoantigen in the Pathogenesis of Sjögren’s Syndrome

Antibodies, 2015
Sjögren’s syndrome, an autoimmune disease characterized by exocrine gland dysfunction leading to dry mouth and dry eye diseases, is typified by lymphoplasmacytic infiltrations and a progressive destruction of the salivary and lacrimal glands.
Takashi Fujimoto, Kiyomi Yoshimoto, Takanori Fujimura, Maiko Takeda, Akiyo Yamauchi, Asako Itaya-Hironaka, Shin Takasawa   +6 more
doaj   +1 more source

Systemic disease-induced salivary biomarker profiles in mouse models of melanoma and non-small cell lung cancer. [PDF]

PLoS ONE, 2009
Saliva (oral fluids) is an emerging biofluid poised for detection of clinical diseases. Although the rationale for oral diseases applications (e.g. oral cancer) is intuitive, the rationale and relationship between systemic diseases and saliva biomarkers ...
Kai Gao, Hui Zhou, Lei Zhang, Jin Wook Lee, Qing Zhou, Shen Hu, Lawrence E Wolinsky, James Farrell, Guido Eibl, David T Wong   +9 more
doaj   +1 more source

SERS Facemask for Rapid and Portable Sensing Mycobacterium Tuberculosis Antigens for TB Screening

Advanced Science, EarlyView.
Our study introduced an Au─Ag embedded covalent organic framework (U@COF) ‐mediated facemask for sensing TB antigen ESAT‐6/CFP‐10 complex in clinical droplet samples toward TB screening. Practical analysis of clinical samples demonstrated the availability of our facemask, which is capable of identifying the TB subjects (N = 17) from healthy candidates (
Lingzhi Chen, Jiaqi Yu, Jing Xu, Lingqi Chen, Ninghao Zhang, Wenrui Li, Runmin Zeng, Xiaomin Luo, Yiqun Chang, Jiayin Lai, Wenshi Huang, Xiaochen Liang, Ting Zhao, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Xueqin Huang, Haibo Zhou, Junxia Zheng   +20 more
wiley   +1 more source

Unprecedented association: Enormous calculus concomitant with salivary gland tumor

Journal of Family Medicine and Primary Care
Calculus represents a mineralized form of bacterial plaque, commonly developing on natural tooth surfaces exposed to a continuous supply of saliva.
Naina Pattnaik, Dhirendra Kumar Singh, Jugajyoti Pathi, NC Sangamesh, Mohammad Jalaluddin, Kumari Lucy Bhola   +5 more
doaj   +1 more source

Eternal dilemma of the interplay between coexisting tuberculosis and malignancy: Clinical scenario of coexisting submandibular carcinoma with disseminated tuberculosis: A case report

Asian Journal of Medical Sciences, 2016
Tuberculosis (TB) and malignancy are two lethal diseases that cause significant morbidity and mortality in developing countries like India. Extrapulmonary tuberculosis (TB) constitutes about 15 to 20 per cent of all cases of tuberculosis with lymph nodes
Manjari Shah
doaj   +1 more source

Parotid sialolithiasis in a two-year-old boy [PDF]

Korean Journal of Pediatrics, 2013
Sialolithiasis is caused by the obstruction of a salivary gland or its excretory duct by the formation of calcareous concretions or sialoliths; this results in salivary ectasia and provokes subsequent dilation of the salivary gland.
Do Hoon Kim, Woo Sun Song, Yeong Jin Kim, Won Duck Kim   +3 more
doaj   +1 more source