Results 191 to 200 of about 32,215 (290)

Adverse Oral Health in Older Adults With Head and Neck Cancer (And Oral Potentially Malignant Disorders): A Systematic Review

Gerodontology, EarlyView.
ABSTRACT Objective This systematic review evaluated oral health, including oral health‐related quality of life (OHRQoL), in older adults with head and neck cancer (HANC) or oral potentially malignant disorders (OPMDs). The PICO/PECO focus question for this study was: ‘What is the incidence/prevalence of adverse oral health (O) among people aged 60 ...
Ciaran Moore, Niamh Walls, Shaima Abujaber, Amanda Willis, Finbarr Allen, Gerry McKenna   +5 more
wiley   +1 more source

Bringing Gene Therapy Into Real World Clinical Practice

Haemophilia, EarlyView.
ABSTRACT Introduction Adeno‐associated virus (AAV)‐based gene therapy for haemophilia has shifted therapeutic paradigms by enabling hepatic gene transfer, restoring endogenous clotting factor expression, and reducing reliance on conventional prophylactic treatments. Two products, valoctocogene roxaparvovec (haemophilia A) and etranacogene dezaparvovec (
Wolfgang Miesbach, Pratima Chowdary, Margareth C. Ozelo   +2 more
wiley   +1 more source

Evaluation of PAX2 and PAX8 expression in salivary gland neoplasms. [PDF]

Head Neck Pathol, 2015
Butler RT, Alderman MA, Thompson LD, McHugh JB.   +3 more
europepmc   +1 more source

Italian Patients Journey for Gene Therapy in Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Gene therapy (GT) provides sustained FVIII levels without repeated infusions in Hemophilia A (HA) patients thus overcoming a major limitation of replacement therapy. However, issues remain e.g., patient selection criteria, duration and variability of transgene expression, quality of life and long‐term safety.
Giovanni Di Minno, Gaia Spadarella, Alessandra Borchiellini, Anna Borrelli, Andrea Buzzi, Giancarlo Castaman, Michele Cecchi, Raimondo De Cristofaro, Vincenzo La Mura, Angelo Lupi, Giuseppe Malcangi, Maria Elisa Mancuso, Maria Francesca Mansueto, Cristina Santoro, Rita Carlotta Santoro, Luigi Piero Solimeno, Annarita Tagliaferri, Ezio Zanon, Isabella Garagiola, Flora Peyvandi   +19 more
wiley   +1 more source

World Health Organization classification of tumours of the breast 6th edition 2026

Histopathology, EarlyView.
The 6th edition of the World Health Organization Classification of Breast Tumours introduces changes based on recent advances in our understanding of breast biology, developments in diagnostic modalities, identification of specific molecular targets and new treatment regimes.
Cecily Quinn, Puay Hoon Tan, Kimberly H Allison, Edi Brogi, Sunil R Lakhani, Stuart J Schnitt, Stephen B Fox, Shabnam Jaffer, Aysegul Sahin, Roberto Salgado, Anna Sapino, Ernest Kwasi Adjei, Katherine Geiersbach, Thomas H Helbich, Matteo Lambertini, Christos Sotiriou, Jennelle C Hodge, Joseph D Khoury, Bharat Rekhi, Ales Ryska, Gary Tse, Andrew Field, Harshima Wijesinghe, Pavitratha Puspanathan, Christine Giesen, Blanca Iciar Indave Ruiz, Ian Ellis, Dilani Lokuhetty, WCT Standing Editorial Board, Wendy Cooper, Michael Eden, Andrew Field, Vicky Goh, Jennelle C. Hodge, James Kench, Joseph D. Khoury, Katia Leite, Zhiyong Liang, Daichi Maeda, George Netto, Bharat Rekhi, Miguel Reyes Mugica, Brian Rous, Ales Ryska, Shahin Sayed, Antonia Sepulveda, Chanjuan Shi, Gary Tse   +47 more
wiley   +1 more source

Sex Differences in Health‐Related Quality of Life in Patients With Head and Neck Cancer—A Prospective Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objective To analyse sex differences in health‐related quality of life (HRQL) before, during and up to 3 months posttreatment of head and neck cancer, and to examine the importance of salivary secretion rate for HRQL posttreatment. Methods Patients were recruited before starting curative oncologic treatment.
Niklas Bohm, Charlott Karlsson, Caterina Finizia, Jessica Skoogh Andersson, Annica Almståhl   +4 more
wiley   +1 more source

Activation of the Urokinase Plasminogen Activator/Urokinase Plasminogen Activator Receptor System in Periodontitis: A Case–Control Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Introduction The plasminogen activating (PA) system has a multitude of functions such as wound healing, proteolytic activity, collagen degradation and cell growth, and the role of the urokinase plasminogen activator/urokinase plasminogen activator receptor (uPA/uPAR) system has been studied in many disease states.
Ahmed Khudhur, Christopher Dowson, Susan M. Bissett, Rachel van de Merwe, John J. Taylor, Philip M. Preshaw, Katrin M. Jaedicke   +6 more
wiley   +1 more source

Australian clinical practice guideline: diagnosis and treatment of idiopathic multicentric Castleman disease

Internal Medicine Journal, EarlyView.
Abstract Idiopathic multicentric Castleman disease (iMCD) is a rare condition. The pathogenesis is incompletely understood; however, interleukin‐6 (IL‐6) is a major mediator. The clinical presentation is heterogeneous, from mild constitutional symptoms to severe multi‐organ failure.
Dipti Talaulikar, Jun Yen Ng, Adam Bryant, Annmarie Bosco, Hugh C. Caterson, Pratyush Giri, Pravin Hissaria, Simon J. Harrison, Stephen Lade, Connull Leslie, Jacinta Perram, H. Miles Prince, Dejan Radeski, Maureen Rischmueller, Craig Wallington‐Gates, Nicholas Weber, Alberta Hoi   +16 more
wiley   +1 more source

Thriving in Nursing Work: The Association Between Self‐Reports and Biomarkers of Stress, Inflammation and Neuroplasticity

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To examine whether self‐reported thriving at work is associated with biomarkers of stress, inflammation, neuroplasticity and neurodegeneration in nurses. Design A cross‐sectional study. Methods An online questionnaire measuring thriving at work was administered to nurses in a teaching hospital in Michigan, U.S. over 5 weeks in 2024.
Judith E. Arnetz, Eamonn Arble, Jackeline Iseler, Michelle Pena, Nicolina Evola, John Vanschagen, John S. Beck, Scott E. Counts, Bengt B. Arnetz   +8 more
wiley   +1 more source

Insomnia and Risk of Tooth Wear and Fracture: Evidence From a Nationwide Population‐Based Cohort

Journal of Oral Rehabilitation, EarlyView.
In this nationwide population‐based cohort study, insomnia was associated with increased risks of tooth wear and tooth fracture. These findings suggest that insomnia may have clinically relevant implications for oral health. ABSTRACT Background Insomnia is associated with various systemic conditions; however, its relationship with structural dental ...
Heon‐Young Kim, Nahyun Kim, Jung‐Hyun Park, Gwang Hyun Leem, Hyo‐Jung Lee, Sooyeon Nam, Heeyeon Kim, Sun‐Jong Kim, Jin‐Woo Kim   +8 more
wiley   +1 more source