Results 81 to 90 of about 173,766 (376)

β‐1,3 Glucan Microparticles & Nanoparticles: Fabrication Methods & Applications in Immunomodulation & Targeted Drug Delivery

Advanced Healthcare Materials, EarlyView.
Beta‐glucans have gained significant attention as an immunomodulatory biomaterial with cell‐targeting capabilities. This review comprehensively outlines the design and fabrication methods for producing beta‐glucan particles at both the micro and nanoscale and their applications in immune cell targeting, immunomodulation, and drug delivery ...
Nate Dowdall, Todd Hoare
wiley   +1 more source

Targeting B cells and plasma cells in autoimmune diseases: From established treatments to novel therapeutic approaches

European Journal of Immunology, Volume 53, Issue 1, January 2023., 2023
B lineage cells have been identified as therapeutic targets in autoimmune diseases. In the current review article, we provide an overview of novel strategies to target B lineage cells in autoimmune diseases, with a focus on inflammatory rheumatic diseases.
Ana Merino‐Vico, Giulia Frazzei, Jan Piet van Hamburg, Sander W. Tas   +3 more
wiley   +1 more source

Salivary gland hypofunction in tyrosylprotein sulfotransferase-2 knockout mice is due to primary hypothyroidism. [PDF]

PLoS ONE, 2013
Protein-tyrosine sulfation is a post-translational modification of an unknown number of secreted and membrane proteins mediated by two known Golgi tyrosylprotein sulfotransferases (TPST-1 and TPST-2).
Andrew D Westmuckett, Joseph C Siefert, Yasvir A Tesiram, David M Pinson, Kevin L Moore   +4 more
doaj   +1 more source

ATG5 is instrumental in the transition from autophagy to apoptosis during the degeneration of tick salivary glands.

PLoS Neglected Tropical Diseases, 2021
Female tick salivary glands undergo rapid degeneration several days post engorgement. This degeneration may be caused by the increased concentration of ecdysone in the hemolymph during the fast feeding period and both autophagy and apoptosis occur.
Yanan Wang, Houshuang Zhang, Li Luo, Yongzhi Zhou, Jie Cao, Xuenan Xuan, Hiroshi Suzuki, Jinlin Zhou   +7 more
doaj   +1 more source

Gland Instance Segmentation Using Deep Multichannel Neural Networks [PDF]

IEEE Transactions on Biomedical Engineering, Volume: 64, Issue: 12, Dec. 2017, Pages: 2901 - 2912, 2016
Objective: A new image instance segmentation method is proposed to segment individual glands (instances) in colon histology images. This process is challenging since the glands not only need to be segmented from a complex background, they must also be individually identified.
arxiv   +1 more source

Interfacial Yield Stress Response in Synthetic Mucin Solutions

Advanced Materials Interfaces, EarlyView.
The solution rheology of novel synthetic mucins mimicking natural mucin domains is studied. Like many natural mucin solutions, apparent solid‐like rheology is seen. However, no bulk structural features are found to explain it. Interfacial rheology and robust modelling reveal that this arises from molecular associations at the air–water interface ...
Sumit Sunil Kumar, Travis Leadbetter, J. Brandon McClimon, Manuel A. Lema, Farhana M. Khan, Prashant K. Purohit, Adam B. Braunschweig, Robert W. Carpick   +7 more
wiley   +1 more source

Hyperpolarization Modulation of the T‐Type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects

Angewandte Chemie, EarlyView.
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka, Yusuke Yano, Nozomi Hara, Chihiro Sadamoto, Andres D. Maturana, Masaki Kita   +5 more
wiley   +2 more sources

Rapid isolation and quantification of extracellular vesicles from suspension‐adapted human embryonic kidney cells using capillary‐channeled polymer fiber spin‐down tips

ELECTROPHORESIS, Volume 44, Issue 1-2, Page 190-202, January 2023., 2023
Abstract Exosomes, a subset of extracellular vesicles (EVs, 30–200‐nm diameter), serve as biomolecular snapshots of their cell of origin and vehicles for intercellular communication, playing roles in biological processes, including homeostasis maintenance and immune modulation.
Kaylan K. Jackson, R. Kenneth Marcus
wiley   +1 more source

Caspase-1 participates in apoptosis of salivary glands in Rhipicephalus haemaphysaloides

Parasites & Vectors, 2017
Background Ticks are among the most harmful vectors worldwide. Their salivary glands play essential roles in blood-feeding and pathogen transmission and undergo apoptosis after feeding.
Xinmao Yu, Yongzhi Zhou, Jie Cao, Houshuang Zhang, Haiyan Gong, Jinlin Zhou   +5 more
doaj   +1 more source

MicroRNAs from saliva of anopheline mosquitoes mimic human endogenous miRNAs and may contribute to vector-host-pathogen interactions [PDF]

, 2019
During blood feeding haematophagous arthropods inject into their hosts a cocktail of salivary proteins whose main role is to counteract host haemostasis, inflammation and immunity. However, animal body fluids are known to also carry miRNAs.
Arcà, Bruno, Benes, Vladimir, Calogero, Raffaele A, Colantoni, Alessio, Di Luca, Marco, Fiorillo, Carmine, Lombardo, Fabrizio, Severini, Francesco   +7 more
core   +3 more sources