Results 61 to 70 of about 208,766 (311)

Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy

Advanced Science, EarlyView.
ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang, Ming Qin, Wenjing Lai, Shiwen Chen, Fengling Wang, Dandan Xie, Maohua Chen, Changpeng Hu, Kui Wang, Rong Zhang, Guobing Li   +10 more
wiley   +1 more source

Economic Factors Effecting Salmon Fisheries in Japan [PDF]

, 2005
わが国の沖合サケ漁業は衰退したが、国産シロザケの生産量はふ化放流事業の成功によって年々増加してきた。しかし、サケ市場が国際化したことによって国産シロザケの産地価格は低迷し続け、わが国のサケ漁業は存続の危機に直面し構造改革を迫られている。国産シロザケの価格変動要因を明らかにするために、北海道の水揚げ港におけるシロザケ価格の短期および長期の変動機構並びに産地市場におけるシロザケの価格形成要因を計量的に分析した。生鮮サケ類産地価格は生鮮サケ類在庫量と生鮮サケマス類輸入量が増加すると低下し ...
清水, 幾太郎, シミズ, イクタロウ, Shimizu, Ikutaro   +2 more
core  

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

The effect of exposure to farmed salmon on piscine orthoreovirus infection and fitness in wild Pacific salmon in British Columbia, Canada.

PLoS ONE, 2017
The disease Heart and Skeletal Muscle Inflammation (HSMI) is causing substantial economic losses to the Norwegian salmon farming industry where the causative agent, piscine orthoreovirus (PRV), is reportedly spreading from farmed to wild Atlantic salmon (
Alexandra Morton, Richard Routledge, Stacey Hrushowy, Molly Kibenge, Frederick Kibenge   +4 more
doaj   +1 more source

Occurrence of Kabatana takedai (Microspora) in Juvenile Masu Salmon (Oncorhynchus masou) reared at Varying Water Temperatures in a Hatchery [PDF]

, 2001
Infections with the microsporidian parasite Kabatana takedai (Awakura, 1974) were monitored for juvenile masu salmon (Oncorhynchus masou) held at various water temperatures controlled using river and spring waters in the Chitose Hatchery, Hokkaido, Japan.
浦和, 茂彦, Urawa, Shigehiko, ウラワ, シゲヒコ   +2 more
core  

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

Implementing interventions that include mentoring components with young people with foster care experience: Lessons learned from the field

Child Protection and Practice
Background: Mentoring programs are popular for youth-serving non-profits, including those serving youth with foster care experience. However, the uptake of quality mentoring programming is a time-consuming endeavor that requires implementation skills ...
Amy M. Salazar, Sara S. Spiers, Deborah G. Fabiyi, Jenna Thompson   +3 more
doaj   +1 more source

Zooplankton of tidal marsh channels in relation to environmental variables in the upper San Francisco Estuary

Aquatic Biology, 2014
Zooplankton are important trophic intermediaries between aquatic primary producers and higher level consumers such as fish, but to date they have been little studied in intertidal marshes.
SM Bollens, JK Breckenridge, JR Cordell, CA Simenstad, O Kalata   +4 more
doaj   +1 more source

Oregon's salmon conservation plan

, 1997
"24 February 1997."This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Mode of access: Internet from the ...

core