Results 181 to 190 of about 51,212 (298)

Circulating angiogenesis‐related biomarkers in sickle cell retinopathy and maculopathy

open access: yesBritish Journal of Haematology, EarlyView.
Summary Sickle cell disease (SCD), encompassing genotypes such as HbSS and HbSC, leads to retinal complications such as sickle cell retinopathy (SCR) and maculopathy (SCM) through poorly understood mechanisms. This study explored associations of a panel of circulating angiogenesis‐related factors with SCR and SCM.
Rajani P. Brandsen   +6 more
wiley   +1 more source

Profiling of HCAR1 signalling reveals Gαi/o and Gαs activation without β‐arrestin recruitment and the discovery of an allosteric agonist

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind   +6 more
wiley   +1 more source

Computing Skinning Weights via Convex Duality

open access: yesComputer Graphics Forum, EarlyView.
We present an alternate optimization method to compute bounded biharmonic skinning weights. Our method relies on a dual formulation, which can be optimized with a nonnegative linear least squares setup. Abstract We study the problem of optimising for skinning weights through the lens of convex duality.
J. Solomon, O. Stein
wiley   +1 more source

Making Inclusive Spaces and Practices With Disabled Children and Young People in Mainstream Education

open access: yesChildren &Society, EarlyView.
ABSTRACT In England, legislation outlines that disabled children and young people should primarily be educated within mainstream provision. Nevertheless, limitations remain in how disabled children and young people experience mainstream educational spaces, particularly those with socio‐emotional and behavioural differences.
Janice Mclaughlin   +5 more
wiley   +1 more source

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