Results 61 to 70 of about 128,090 (276)

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Engineering New‐to‐Nature Biological Pathways for β,γ‐Alkanediol Synthesis

Advanced Science, EarlyView.
β,γ‐Alkanediols are value‐added chemicals to be used as functional solvents, biofuels, and cosmetic components. This work demonstrates a carboligation‐mediated approach for synthesis of linear chain β,γ‐alkanediols in Escherichia coli, namely, hexane‐2,3‐diol (2,3‐HDO) and pentane‐2,3‐diol (2,3‐PDO). The engineered E. coli cells produce 152.2 mm (17.98
Haofeng Chen, Haidong Yu, Dongjiang Lin, Guojun Yang, Yuchen Xie, Yang Zhang, Jifeng Yuan   +6 more
wiley   +1 more source

Salmonella entericain Pinnipeds, Chile

Emerging Infectious Diseases, 2011
To the Editor: Several wildlife-associated zoonotic agents have played a major role in the emergence of diseases in humans (1). However, diseases can also emerge in wildlife as a result of human activities, such as contamination of the marine environment and its fauna by the disposal of nontreated human sewage.
Sturm, Natalie, Abalos Pineda, Pedro, Fernandez, Alda, Rodriguez, Guillermo, Oviedo, Pilar, Arroyo, Viviana, Peñailillo Retamal, Patricio Alejandro   +6 more
openaire   +4 more sources

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Prevalence of enterobacteriaceae in Tupinambis merianae (Squamata: Teiidae) from a captive facility in Central Brazil, with a profile of antimicrobial drug resistance in Salmonella enterica [PDF]

Phyllomedusa: Journal of Herpetology, 2013
The present study reports the presence of enterobacteriaceae in Tegu Lizards (Tupinambis merianae)from a captive facility in central Brazil. From a total of 30 animals, 10 juveniles and 20 adults (10 males, 10 females), 60 samples were collected, in two ...
Andréa de Moraes Carvalho, Ayrton Klier Péres Júnior, Maria Auxiliadora Andrade, Valéria de Sá Jayme   +3 more
doaj   +2 more sources

FabR regulates Salmonella biofilm formation via its direct target FabB [PDF]

, 2016
Background: Biofilm formation is an important survival strategy of Salmonella in all environments. By mutant screening, we showed a knock-out mutant of fabR, encoding a repressor of unsaturated fatty acid biosynthesis (UFA), to have impaired biofilm ...
De Coster, David, De Keersmaecker, Sigrid CJ, Hermans, Kim, Kint, Gwendoline, Marchal, Kathleen, Roberfroid, Stefanie, Steenackers, Hans P, Thijs, Inge M, Vanderleyden, Jos   +8 more
core   +4 more sources

Recombination and Population Structure in Salmonella enterica [PDF]

PLoS Genetics, 2011
Salmonella enterica is a bacterial pathogen that causes enteric fever and gastroenteritis in humans and animals. Although its population structure was long described as clonal, based on high linkage disequilibrium between loci typed by enzyme electrophoresis, recent examination of gene sequences has revealed that recombination plays an important ...
Didelot, Xavier, Bowden, Rory, Street, Teresa, Golubchik, Tanya, Spencer, Chris, McVean, Gil, Sangal, Vartul, Anjum, Muna, Achtman, Mark, Falush, Daniel, Donnelly, Peter   +10 more
openaire   +9 more sources

A Genomic Catalog of Migratory Microbiomes from Wild Birds across China's Habitats

Advanced Science, EarlyView.
ABSTRACT Migratory birds play an important role in the spread of antimicrobial resistance (AMR); however, gaps in surveillance data from vital regions along migratory flyways across China limit the detection of emergent threats. Here, we assembled 340 metagenomes from 52 bird species covering 11 provincial administrative districts in China, presenting ...
Yanan Wang, Heqi Wu, Mengqi Qu, Chunge Zhang, Ziqian Xu, Yuhang Pei, Chaochao Zhao, Jiangtao Wang, Sufang Ma, Na Lyu, Xuebin Xu, Yuhai Bi, Baoli Zhu, George F. Gao   +13 more
wiley   +1 more source

Comparison of three diagnostic methods for Salmonella enterica serovars detection in chicken rinse

Pesquisa Veterinária Brasileira
: Salmonella detection is a key point in food safety testing, because of the frequent association of this pathogen with food poisoning in humans. The standard bacteriological tests currently used for Salmonella-detection are time-consuming; therefore ...
Isadora M.O. Corrêa, Larissa Q. Pereira, Isabella G.O. Silva, Rafaela Altarugio, Bruna D. Smaniotto, Tarcísio M. Silva, Adriano S. Okamoto, Raphael L. Andreatti Filho   +7 more
doaj   +1 more source

Emerg. Infect. Dis [PDF]

, 2008
The multidrug-resistant (MDR) Salmonella enterica serotype Newport strain that produces CMY-2 β-lactamase(Newport MDR-AmpC) was the source of sporadic cases and outbreaks in humans in France during 2000–2005.
Achtman, M., Delaune, A., Demartin, M., Egorova, S., Espie, E., Fabre, L., Granier, S., Grimont, P., Millemann, Y., Pardos, M., Sangal, V., Timinouni, M., Weill, F., Whichard, J.   +13 more
core   +1 more source