Results 81 to 90 of about 103,325 (238)

Molecular detection of pathogens in an equine fever diagnostic panel: 2019–2023

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background A common diagnostic approach for febrile horses is to test for a panel of potential pathogens. Panels are curated by expert opinion and vary between diagnostic laboratories. Objectives To report the results of a newly developed equine fever diagnostic panel (EFDP) between 2019 and 2023 and evaluate the frequency of positive results.
Toby L. Pinn‐Woodcock   +3 more
wiley   +1 more source

Protein nanoparticles assemble in plants, display antigenic viral peptides, and produce an epitope‐specific immune response

open access: yesThe FEBS Journal, EarlyView.
Current methods to control porcine reproductive and respiratory syndrome, a disease affecting pigs, are insufficient and a safer, more effective vaccine is needed. This study describes the design and plant production of a self‐assembling protein nanoparticle vaccine candidate against this disease.
Jordan T. VanderBurgt   +5 more
wiley   +1 more source

Zebrafish as a model for Catel–Manzke syndrome—identification and characterization of the zebrafish TGDS ortholog

open access: yesThe FEBS Journal, EarlyView.
Zebrafish Tgds, when expressed as a recombinant protein, catalyzes the dehydration of UDP‐D‐glucose, the initial step in the formation of 6‐deoxyhexoses. Corresponding Tgds mutations found in Catel–Manzke syndrome patients lead to reduced enzymatic activity and stability.
Maria Rosaria Coppola   +11 more
wiley   +1 more source

Molecular basis of antibiotic sensing by the TetR family regulator CecR – a structural perspective

open access: yesThe FEBS Journal, EarlyView.
Escherichia coli CecR, a member of the TetR family regulators, senses selected antibiotics and activates the expression of a putative drug efflux pump. Although present in many pathogenic Enterobacteriales strains, CecR remains poorly characterized. We present the first CecR crystal structure, which reveals a unique tunnel‐like ligand‐binding cavity ...
Agnieszka J. Pietrzyk‐Brzezinska   +5 more
wiley   +1 more source

A rapid and specific detection of pathogenic serovar Salmonella typhimurium by loop-mediated isothermal amplification method (LAMP) [PDF]

open access: yesBiological Journal of Microorganism, 2017
Introduction:Salmonella serovar typhimurium is one of the most important foodborne pathogens and common causes of salmonellosis that in some conditions lead to septicemia or even death in humans.
Hadi Ravan, Mojdeh Amandadi
doaj  

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

open access: yesImmunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu   +24 more
wiley   +1 more source

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease

open access: yesJournal of Internal Medicine, EarlyView.
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron   +3 more
wiley   +1 more source

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