Results 71 to 80 of about 3,166,358 (335)

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Effect of Pulsed or Continuous Delivery of Salt on Sensory Perception Over Short Time Intervals [PDF]

, 2009
Salt in the human diet is a major risk factor for hypertension and many countries have set targets to reduce salt consumption. Technological solutions are being sought to lower the salt content of processed foods without altering their taste.
A Okiyama, Andrew J. Taylor, Anne-Laure Koliandris, B Johansson, Bettina Wolf, BP Halpern, BP Halpern, Cecile Morris, DG Laing, DH McBurney, E Neyraud, F Angus, G Pasin, H Abrahams, H Tuorila, HL Meiselman, HL Meiselman, HR Moskowitz, HT Lawless, J Hort, Joanne Hort, K Wendin, LM Duizer, MJM Theunissen, MJM Theunissen, P Overbosch, PGJ Ganzevles, RW Visschers, S Desobry-Bandon, S Yamaguchi, SP Chi, WE Lee, YH Liu, Z Bujas   +33 more
core   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Attraction between DNA molecules mediated by multivalent ions [PDF]

, 2003
The effective force between two parallel DNA molecules is calculated as a function of their mutual separation for different valencies of counter- and salt ions and different salt concentrations.
A. A. Kornyshev, A. A. Kornyshev, A. E. Larsen, A. K. Sood, A. Katchalsky, A. P. Lyubartsev, A. P. Lyubartsev, B. Jayaram, B. R. Svennson, B. S. Fujimoto, C. J. Coen, C. L. Steven, C. S. Murthy, D. C. Rau, D. C. Rau, D. Goulding, E. Allahyarov, E. J. W. Vervey, G. Gompper, G. Lamm, G. Lamm, H. A. Tajmir-Riahi, H. Deng, H. Löwen, H. N. W. Lekkerkerker, I. Fita, J. A. Benbasat, J. Conrad, J. L. Barrat, J. L. Hecht, J. Lekner, J. Z. Wu, K. Wagner, L. E. Guldbrand, L. G. Nilsson, L. Yang, M. D. Paulsen, M. Deserno, M. Farnum, M. Feig, M. J. Stevens, M. K. Gilson, M. Lozada-Cassou, M. P. Allen, N. Grønbech-Jensen, N. Grønbech-Jensen, N. Korolev, P. Attard, P. Attard, P. Mills, R. Kjellander, R. Kjellander, R. Podgornik, R. Podgornik, S. E. Feller, S. Gavryushov, T. Das, V. A. Bloomfield, V. A. Bloomfield, V. Vlachy, W. Saenger, X. E. Cai, Y. Burak   +62 more
core   +2 more sources

Construction of hyperthermostable d‐allulose 3‐epimerase from Arthrobacter globiformis M30 using the sequence information from Arthrobacter psychrolactophilus

FEBS Open Bio, EarlyView.
d‐Allulose can be produced from d‐fructose by d‐allulose 3‐epimerase. Based on sequence homology information, we successfully engineered thermostable mutants with the protein engineering method. By integrating positive mutations, we constructed an enzyme that exhibits hyperthermostability without a loss in the activity.
Kensaku Shimada, Kouhei Ohtani, Pushpa Kiran Gullapalli, Kazuhiko Ishikawa   +3 more
wiley   +1 more source

Evidence of road salt in New Hampshire’s snowpack hundreds of meters from roadways [PDF]

, 2017
Salinization of surface and groundwater has been directly linked to the area of road surfaces in a watershed and the subsequent wintertime maintenance used to keep roads free of snow and ice.
Dibb, Jack E., Lazarcik, James
core   +4 more sources

Biophysical characterization and ion transport with cell‐based and proteoliposome reconstitution assays of invertebrate K+‐Cl− cotransporters

FEBS Open Bio, EarlyView.
The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo, Marina Verkhovskaya, Coralie Di Scala, Claudio Rivera, Tommi Kajander   +4 more
wiley   +1 more source

Experimental salt marsh islands: a model system for novel metacommunity experiments [PDF]

, 2017
Shallow tidal coasts are characterised by shifting tidal flats and emerging or eroding islands above the high tide line. Salt marsh vegetation colonising new habitats distant from existing marshes are an ideal model to investigate metacommunity theory ...
Balke, Thorsten, Haynert, Kristin, Hillebrand, Helmut, Hodapp, Dorothee, Kleyer, Michael, Lõhmus, Kertu, Meier, Daniela, Minden, Vanessa, Zielinski, Oliver   +8 more
core   +2 more sources

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Loving over Skype: Tactile Viewing, Emotional Atmospheres and Video Calling

Journal of Popular Romance Studies, 2017
This article draws on research interviews taken from a broader research project, The Love Migration Project, the aim of which is to understand how and why people move for love.
Yvonne Clarke-Salt
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