Results 41 to 50 of about 297,890 (267)

Salt-inducible expression of OsJAZ8 improves resilience against salt-stress [PDF]

BMC Plant Biology, 2018
Productivity of important crop rice is greatly affected by salinity. The plant hormone jasmonate plays a vital role in salt stress adaptation, but also evokes detrimental side effects if not timely shut down again. As novel strategy to avoid such side effects, OsJAZ8, a negative regulator of jasmonate signalling, is expressed under control of the salt ...
Peethambaran, Preshobha K., Glenz, Rene, Hoeninger, Sabrina, Islam, S. M. Shahinul, Hummel, Sabine, Harter, Klaus, Kolukisaoglu, Uener, Meynard, Donaldo, Guiderdoni, Emmanuel, Nick, Peter, Riemann, Michael   +10 more
openaire   +9 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Exogenous Salicylic Acid-Mediated Physiological Responses and Improvement in Yield by Modulating Antioxidant Defense System of Wheat under Salinity

Notulae Scientia Biologicae, 2017
Present study investigates the regulatory roles of exogenous salicylic acid (SA) in physiology, antioxidant defense systems and yield of wheat under different salt stress condition. The experiment was conducted with two varieties i.e.
Jannatul FARDUS, Md. Abdul MATIN, Md. HASANUZZAMAN, Md. Shahadat HOSSAIN, Sheymol Dev NATH, Md. Amzad HOSSAIN, Md. Motiar ROHMAN, Mirza HASANUZZAMAN   +7 more
doaj   +1 more source

Salt stress induces endoplasmic reticulum stress-responsive genes in a grapevine rootstock.

PLoS ONE, 2020
Grapevines, although adapted to occasional drought or salt stress, are relatively sensitive to growth- and yield-limiting salinity stress. To understand the molecular mechanisms of salt tolerance and endoplasmic reticulum (ER) stress and identify genes ...
Birsen Çakır Aydemir, Canan Yüksel Özmen, Umut Kibar, Filiz Mutaf, Pelin Burcu Büyük, Melike Bakır, Ali Ergül   +6 more
doaj   +1 more source

Genome-Wide Association Studies of Salt Tolerance at Seed Germination and Seedling Stages in Brassica napus

Frontiers in Plant Science, 2022
Most crops are sensitive to salt stress, but their degree of susceptibility varies among species and cultivars. In order to understand the salt stress adaptability of Brassica napus to salt stress, we collected the phenotypic data of 505 B.
Guofang Zhang, Guofang Zhang, Jinzhi Zhou, Yan Peng, Zengdong Tan, Zengdong Tan, Long Li, Long Li, Liangqian Yu, Liangqian Yu, Cheng Jin, Shuai Fang, Shuai Fang, Shaoping Lu, Shaoping Lu, Liang Guo, Liang Guo, Xuan Yao, Xuan Yao   +18 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Salt‑responsive transcriptome analysis of canola roots reveals candidate genes involved in the key metabolic pathway in response to salt stress

Scientific Reports, 2022
Salinity is a major constraint on crop growth and productivity, limiting sustainable agriculture in arid regions. Understanding the molecular mechanisms of salt-stress adaptation in canola is important to improve salt tolerance and promote its ...
Weichao Wang, Jiayin Pang, Fenghua Zhang, Lupeng Sun, Lei Yang, Tingdong Fu, Liang Guo, Kadambot H. M. Siddique   +7 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Transcription elongation factor AtSPT4-2 positively modulates salt tolerance in Arabidopsis thaliana

BMC Plant Biology, 2023
Background Salt stress significantly influences plant growth and reduces crop yield. It is highly anticipated to develop salt-tolerant crops with salt tolerance genes and transgenic technology.
Ayesha Liaqat, Alamin Alfatih, Sami Ullah Jan, Liangqi Sun, Pingxia Zhao, Chengbin Xiang   +5 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source