Results 61 to 70 of about 341,966 (310)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

qRT-PCR analyses of nine salt-stress-induced DEGs in asparagus bean under salt stress.

, 2019
qRT-PCR analyses of nine salt-stress-induced DEGs in asparagus bean under salt stress.
Tong Gao (341025), Yu Zheng (2950), Xiaolu Yu (5081609), Chen Zeng (34338), Jingjie Shao (6948845), Chengzhi Liang (14320), Zhichao Liu (191718), Lei Pan (191007), Chanyou Chen (6108437)   +8 more
core   +1 more source

Exogenous Salicylic Acid-Mediated Physiological Responses and Improvement in Yield by Modulating Antioxidant Defense System of Wheat under Salinity

Notulae Scientia Biologicae, 2017
Present study investigates the regulatory roles of exogenous salicylic acid (SA) in physiology, antioxidant defense systems and yield of wheat under different salt stress condition. The experiment was conducted with two varieties i.e.
Jannatul FARDUS, Md. Abdul MATIN, Md. HASANUZZAMAN, Md. Shahadat HOSSAIN, Sheymol Dev NATH, Md. Amzad HOSSAIN, Md. Motiar ROHMAN, Mirza HASANUZZAMAN   +7 more
doaj   +1 more source

Salt‑responsive transcriptome analysis of canola roots reveals candidate genes involved in the key metabolic pathway in response to salt stress

Scientific Reports, 2022
Salinity is a major constraint on crop growth and productivity, limiting sustainable agriculture in arid regions. Understanding the molecular mechanisms of salt-stress adaptation in canola is important to improve salt tolerance and promote its ...
Weichao Wang, Jiayin Pang, Fenghua Zhang, Lupeng Sun, Lei Yang, Tingdong Fu, Liang Guo, Kadambot H. M. Siddique   +7 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Responses and tolerance to salt stress in bryophytes [PDF]

Plant Signaling & Behavior, 2008
During exposure to salt environments, plants could perceive salt signal and transmit the signal to cellular machinery to activate adaptive responses. In bryophytes, salt signal components and transcript factor identified suggest that salt activate adaptive responses to tolerate adverse environments.
Xiaoqin, Wang, Zheng, Liu, Yikun, He
openaire   +2 more sources

Staphylococcus aureus: salt stress, cell wall deficiency, and Biofílm formation [PDF]

, 2008
Staphylococcus aureus (S. aureus) is a major cause of chronic infection and is of particular concern in the infection of implanted prostheses. Biofilm formation offers bacteria innate protection from antimicrobial agents and prevents the eradication of ...
Beckingsale, Thomas
core  

Research advances of salt exclusion, salt sequestration, salt secretion, and salt signaling regulation in plants

Plant Stress
Salt stress is one of the main environmental stress factors with increasing negative impacts on agricultural production worldwide, posing serious threats to global food security.
Yanchun Zhu, Mengxia Li, Tao Wang, Jinyu Wang, Hongkai Zhou, Yongjun Lin, Changxi Yin   +6 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Effect of increasing salinity on growth and mineral composition of wheat varieties and role of sodium exclusion capacity in salt tolerance mechanisms

, 2002
A few wheat varieties including two Japanese wheat varieties were evaluated for their salt tolerance at seeding stage, their behavior to increasing salinity levels and role of Na exclusion capacity in salt tolerance mechanisms.
Adachi, Tadashi, Oki, Yoko, Kamboh, Maqsood Ahmed   +2 more
core   +1 more source