Results 61 to 70 of about 4,791,077 (313)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Salt‑responsive transcriptome analysis of canola roots reveals candidate genes involved in the key metabolic pathway in response to salt stress

Scientific Reports, 2022
Salinity is a major constraint on crop growth and productivity, limiting sustainable agriculture in arid regions. Understanding the molecular mechanisms of salt-stress adaptation in canola is important to improve salt tolerance and promote its ...
Weichao Wang, Jiayin Pang, Fenghua Zhang, Lupeng Sun, Lei Yang, Tingdong Fu, Liang Guo, Kadambot H. M. Siddique   +7 more
doaj   +1 more source

Proline-Induced Modifications in Morpho-Physiological, Biochemical and Yield Attributes of Pea (Pisum sativum L.) Cultivars under Salt Stress [PDF]

, 2022
Sadia Shahid, Muhammad Shahbaz, Muhammad Faisal Maqsood, Fozia Farhat, Usman Zulfiqar, Talha Javed, Muhammad Fraz Ali, Majid Alhomrani, Abdulhakeem S. Alamri   +8 more
openalex   +1 more source

Melatonin promotes seed germination under salt stress by regulating ABA and GA3 in cotton (Gossypium hirsutum L.).

Plant physiology and biochemistry : PPB, 2020
Although previous studies have found that melatonin can promote seed germination, the phytohormone regulation mechanism by which exogenous melatonin mediates salt tolerance during cotton seed germination is still largely unknown. The effects of melatonin
Li Chen, B. Lu, Liantao Liu, Wen-jing Duan, Dan Jiang, Jin Li, Ke Zhang, Hongchun Sun, Yongjiang Zhang, Cundong Li, Zhiying Bai   +10 more
semanticscholar   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Exogenous Salicylic Acid-Mediated Physiological Responses and Improvement in Yield by Modulating Antioxidant Defense System of Wheat under Salinity

Notulae Scientia Biologicae, 2017
Present study investigates the regulatory roles of exogenous salicylic acid (SA) in physiology, antioxidant defense systems and yield of wheat under different salt stress condition. The experiment was conducted with two varieties i.e.
Jannatul FARDUS, Md. Abdul MATIN, Md. HASANUZZAMAN, Md. Shahadat HOSSAIN, Sheymol Dev NATH, Md. Amzad HOSSAIN, Md. Motiar ROHMAN, Mirza HASANUZZAMAN   +7 more
doaj   +1 more source

Transcription elongation factor AtSPT4-2 positively modulates salt tolerance in Arabidopsis thaliana

BMC Plant Biology, 2023
Background Salt stress significantly influences plant growth and reduces crop yield. It is highly anticipated to develop salt-tolerant crops with salt tolerance genes and transgenic technology.
Ayesha Liaqat, Alamin Alfatih, Sami Ullah Jan, Liangqi Sun, Pingxia Zhao, Chengbin Xiang   +5 more
doaj   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

GmNAC06, a NAC domain transcription factor enhances salt stress tolerance in soybean

Plant Molecular Biology, 2020
We found GmNAC06 plays an important role in salt stress responses through the phenotypic, physiological and molecular analyses of OE, VC, and Mutant composite soybean. Salinization affects 20% of all cultivated land worldwide because of the high salinity
Ming Li, Rui Chen, Q. Jiang, Xian-jun Sun, Hui Zhang, Zheng Hu   +5 more
semanticscholar   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source