Results 71 to 80 of about 914,128 (310)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Formic acid enhances whole-plant mulberry silage fermentation by boosting lactic acid production and inhibiting harmful bacteria

Frontiers in Microbiology
Mulberry has also been regarded as a valuable source of forage for ruminants. This study was developed to investigate the impact of four additives and combinations thereof on fermentation quality and bacterial communities associated with whole-plant ...
Lihong Hao, Lihong Hao, Fugui Jiang, Fugui Jiang, Yanping Wang, Yanping Wang, Huaizhong Wang, Huaizhong Wang, Hongmei Hu, Hongmei Hu, Wei You, Wei You, Xin Hu, Xin Hu, Haijian Cheng, Haijian Cheng, Cheng Wang, Cheng Wang, Enliang Song, Enliang Song, Enliang Song   +20 more
doaj   +1 more source

Intra-body microwave communication through adipose tissue

Healthcare Technology Letters, 2017
The human body can act as a medium for the transmission of electromagnetic waves in the wireless body sensor networks context. However, there are transmission losses in biological tissues due to the presence of water and salts.
Noor Badariah Asan, Daniel Noreland, Emadeldeen Hassan, Syaiful Redzwan Mohd Shah, Anders Rydberg, Taco J. Blokhuis, Per-Ola Carlsson, Thiemo Voigt, Robin Augustine   +8 more
doaj   +1 more source

INVESTIGATION OF ENVIRONMENTAL IMPACTS ON SANDSTONE BLOCKS AT LUXOR TEMPLE AND CONCEPTS FOR CONSERATION [PDF]

Journal of the General Union of Arab Archaeologists, 2016
Sandstone blocks were used in the construction of Luxor temple. However, they, especialy cement materials, were at a great risk because of being affected by various deterioration factors.
Elashmawy Ahmed
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Influencia del uso del suelo en su calidad ambiental en medio semiárido (Murcia SE España) Soil environmental quality related to different soil uses in a semiarid zone (Murcia SE Spain)

Revista de Ciências Agrárias, 2010
La agricultura intensiva y las activida­des mineras se encuentran entre las prin­cipales fuentes de contaminación del sue-lo ocasionando con frecuencia la acumu­lación en el mismo de sales solubles, nu­trientes, metales pesados, etc., con la con ...
J. A. Hernández, M. T. Fernández, A. Ortuño, M. A. Alarcón   +3 more
doaj  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Modified polyurethane foams for fuel-fire Patent [PDF]

, 1970
Modification of polyurethanes with alkyl halide resins, inorganic salts, and encapsulated volatile and reactive halogen for fuel fire ...
Parker, J. A., Riccitiello, S. R.
core   +1 more source

Ion-specificity in {\alpha}-helical folding kinetics

, 2010
The influence of the salts KCl, NaCl, and NaI at molar concentrations on the {\alpha}-helical folding kinetics of the alanine-based oligopeptide Ace-AEAAAKEAAAKA-Nme is investigated by means of (explicit-water) molecular dynamics simulations and a ...
Dzubiella, Joachim, Kalcher, Immanuel, von Hansen, Yann   +2 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source