Results 61 to 70 of about 16,396,047 (272)

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

open access: yesAdvanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton   +13 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

open access: yesAngewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma   +5 more
wiley   +2 more sources

Linking Ontogenetic, Seasonal, and Spatial Variability in the Trophic Biology of Citharichthys spilopterus to Environmental Conditions in a Tropical Estuary

open access: yesFishes
The flatfish Citharichthys spilopterus is a common predatory species in the estuaries of the southwestern Gulf of Mexico. In general, factors controlling the foraging behavior of fish can be extrinsic (environmental conditions) or intrinsic (size-related
Castillo-Rivera Manuel   +1 more
doaj   +1 more source

Política de atención a la Salud del hombre en Brasil y los retos de su implantación: una revisión integrativa

open access: yesEnfermería Global, 2013
ABSTRACT This study aims to identify the challenges for the implementation of the National Policy for Integral Attention to human health. It is an integrative review consisted of searching the databases LILACS, SciELO and BDENF the period between 2000 and 2012.
Da Silva Nogueira, Patrick Leonardo   +4 more
openaire   +5 more sources

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

open access: yesAdvanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang   +6 more
wiley   +1 more source

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

open access: yesAngewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

Homens, vítimas e autores de violência: a corrosão do espaço público e a perda da condição humana

open access: yesInterface: Comunicação, Saúde, Educação, 2012
Trata-se de estudo qualitativo, realizado no Município de Ribeirão das Neves-MG, com o objetivo de compreender o envolvimento dos homens com a violência.
Rejane Aparecida Alves   +4 more
doaj  

Relevancia de la menopausia y del apoyo social en las diferencias en salud entre mujeres y hombres

open access: yesUniversitas Psychologica, 2017
Se analizó la relevancia de la menopausia y el apoyo social en las diferencias en salud entre mujeres y hombres mediante un estudio transversal realizado con 710 mujeres y 606 hombres de la población general española con edades entre 20 y 65 años. Se encontró que, aunque en la juventud apenas había diferencias entre hombres y mujeres, a partir de la ...
Matud Aznar, Ma Pilar   +2 more
openaire   +3 more sources

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

open access: yesAdvanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu   +7 more
wiley   +1 more source

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