Results 71 to 80 of about 586,963 (259)

Holism and qualitative research within the framework of the anthropology of complexity. A reflection on the methodological pertinence in socio-sanitary and human sciences [PDF]

, 2005
Este estudio se ha orientado partiendo de los siguientes objetivos: Vincular el principio de pertinencia metodológica e instrumental a las características del objeto-sujeto investigado en el marco epistemológico de una disciplina.
Cibanal Juan, Luis, Siles González, José, Solano-Ruiz, MCarmen   +2 more
core   +1 more source

SKOOTS: Skeleton‐Oriented Object Segmentation for Mitochondria in High‐Resolution Cochlear EM Datasets

Advanced Science, EarlyView.
Skeleton‐oriented object segmentation (SKOOTS) introduces a new strategy for 3D mitochondrial instance segmentation by predicting explicit skeletons rather than relying on boundary cues. This approach enables robust analysis of densely packed organelles in large FIB‐SEM datasets.
Christopher J. Buswinka, Richard T. Osgood, Hidetomi Nitta, Artur A. Indzhykulian   +3 more
wiley   +1 more source

Spartan Daily, November 9, 2017 [PDF]

, 2017
Volume 149, Issue 34https://scholarworks.sjsu.edu/spartan_daily_2017/1075/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

La filosofía, el proceso salud-enfermedad y el medio ambiente The philosophy, the process health-illness and the environment

Revista Habanera de Ciencias Médicas, 2012
Introducción: la calidad de vida depende directamente del medio natural y su calidad. La valoración sobre la salud no solo obedece a las necesidades y los conocimientos del individuo, sino también a las condiciones de vida y trabajo y del medio donde se ...
Marilys Hernández Cabezas, Maricelys Hernández Cabezas, José Luis Mauri Pérez, Vilma García Franco   +3 more
doaj  

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Necessidades de saúde de homens na atenção básica: acolhimento e vínculo como potencializadores da integralidade

Escola Anna Nery, 2013
Este estudo teve como objetivo analisar as necessidades de saúde de homens usuários de uma unidade básica de saúde, na cidade de Belo Horizonte/Minas Gerais.
Luisa Pereira Storino, Kleyde Ventura de Souza, Kênia Lara Silva   +2 more
doaj   +1 more source

Salud colectiva : donde eficiencia y justicia social van de la mano [PDF]

Fil: Escudero, José Carlos. Universidad Nacional de La Plata; Argentina.¿La salud debe ser un derecho de todos o un bien más al que sólo deben tener acceso quienes\nposeen los recursos necesarios para comprarlo?
Escudero, José Carlos
core  

A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer

Advanced Science, EarlyView.
A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang, Xiang Chen, Xiaoxiao Yang, Muskan Gori, Rohit Kumar Varshnaya, Dongning Liu, Cheryl Zhang, Michelle Yi Qin Chen, Zhengming Chen, George Zhang, Erika Patel, Qiyue Mao, Tan A. Ince, Chalet Tan, Binghe Wang, Yi‐Chieh Nancy Du   +15 more
wiley   +1 more source