Results 91 to 100 of about 7,645 (185)

Changes in Oxygen Metabolism Biomarkers of Ischemic Tissue Treated With Electrical Stimulation. [PDF]

Stroke Vasc Interv Neurol
Bahr-Hosseini M, Asghariahmadabad M, Bikson M, Saver JL, Liebeskind DS, Nael K.   +5 more
europepmc   +1 more source

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

Salvage of locoregionally recurrent head and neck cancer: an NRG oncology working group review. [PDF]

J Natl Cancer Inst
Ward MC, Kang JJ, Saba NF, Campbell SR, Akhave NS, Chang SS, Spencer SA, Spreafico A, Hanna GJ, Yom SS, Heron DE.   +10 more
europepmc   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Mitochondrial-Localized Keratin 17 Promotes Chemoresistance in Basal-like Pancreatic Cancer. [PDF]

Cancer Res
Pan CH, Lyu Y, Ghosh M, Siraj MA, Tseng R, Chaika NV, Haley JD, Khalvatifahlylani B, Tuveson DA, Patel HD, Faruque M, Rajacharya GH, Donnelly KL, Leiton CV, Mejia Arbelaez CM, Chen H, Chowdhury S, Sarkar S, Delgado Coka L, Roa-Peña L, Horowitz M, Marchenko N, Singh PK, Shroyer KR, Escobar-Hoyos LF.   +24 more
europepmc   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Anti-thymocyte globulin in immune-mediated cytopenias: A monocentric experience and literature review. [PDF]

Br J Haematol
Guarnera L, Ahmed A, Bravo-Perez C, Ogbue OD, D'Addona M, Brady Z, Unlu S, Haddad C, Mandala A, Durmaz A, Gurnari C, Visconte V, Maciejewski JP.   +12 more
europepmc   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Understanding Patient Preferences Regarding Limb Salvage for Diabetic Foot Ulcers: A Discrete Choice Experiment. [PDF]

Diabetes Care
O'Hara LM, Lydecker AD, Robinson GL, O'Hara NN, Kim JJ, Littman AJ, Schmidt BM, Addison O, Margolis DJ, Roghmann MC.   +9 more
europepmc   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source