Results 71 to 80 of about 17,782 (219)

A Universal Hairy Root Transformation Protocol for Evaluating Editing Efficiency in Dicot Plants

Modern Agriculture, Volume 4, Issue 1, June 2026.
A streamlined workflow for the rapid evaluation of CRISPR‐Cas9 editing efficiency using a universal Agrobacterium rhizogenes–mediated hairy root transformation system. The process encompasses seed germination, explant preparation, bacterial infection, hairy root induction, and comprehensive validation of editing events via Sanger sequencing, PCR ...
Hong Yang, Yirang Jiao, Wenjing Sun, Taotao Zhu, Juan Guo, Huawei Zhang   +5 more
wiley   +1 more source

Simultaneous Determination of Four Tanshinones by UPLC-TQ/MS and Their Pharmacokinetic Application after Administration of Single Ethanol Extract of Danshen Combined with Water Extract in Normal and Adenine-Induced Chronic Renal Failure Rats

Molecules, 2016
Salvia miltiorrhiza, one of the major traditional Chinese medicines, is commonly used and the main active ingredients—tanshinones—possess the ability to improve renal function.
Hong-Die Cai, Shu-Lan Su, Yonghui Li, Zhenhua Zhu, Jianming Guo, Yue Zhu, Sheng Guo, Dawei Qian, Jinao Duan   +8 more
doaj   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

Evaluation of Tanshinone IIA Developmental Toxicity in Zebrafish Embryos

Molecules, 2017
Tanshinone IIA (Tan-IIA) is derived from the dried roots of Salvia miltiorrhiza Bunge, a traditional Chinese medicine. Although Salvia miltiorrhiza has been applied for many years, the toxicity of the mono-constituent of Salvia miltiorrhiza, tanshinone ...
Tao Wang, Chengxi Wang, Qiong Wu, Kangdi Zheng, Jiaojiao Chen, Yutao Lan, Yao Qin, Wenjie Mei, Baoguo Wang   +8 more
doaj   +1 more source

Drugs and herbs given to prevent hepatotoxicity of tuberculosis therapy: systematic review of ingredients and evaluation studies [PDF]

, 2008
Background: Drugs to protect the liver are frequently prescribed in some countries as part of treatment for tuberculosis. The biological rationale is not clear, they are expensive and may do harm.
Qin Liu, Paul Garner, Yang Wang, Binghua Huang, Helen Smith, MJ Ho, F Stickel, M Steele, YJ Guo, DR Zhang, DY Hu, S Zhan, World Health Organization Division of Traditional Medicine, R Wang, LM Li, VK Singh, QH Huang, LA Galitskií, HR Li, BC Xing, Q Liu, XM Zheng, XP Hao, HR Li, W Bao, GF An, AG Dong, Y Gao, ZH Huang, HY Zhang, Z Zhang, L Tian, YJ Wei, J Chang, YX Chen, XH Chen, ZJ Chai, LJ Fu, NP Skakun, Wl Zhu, JF Cheng, GP Jin, Sl Yu, JQ Xiao, YM Wu, SW Kang, HQ Pan, JF Ge, L Tian, P Zhang, YM Li, SL Liang, BQ Fu, B Chen, YK Chen, KZ Du, SV Dange, OI Katikova, S Yang, Y Yuan, P Sun, QH Zhang, XF Zhang, WL Wang, JF Cheng, LF He, X Zhang, CJ Ye, RM Sun, ZD Wang, Q Zhu, FJ Liu, LW Wu, ZC Niu, GY Ding, B Liu, K Lan, Q Tan, ZG Bi, LL Liang, B Quan, LY Ma, JJ Wu, J Liu, XL Li, L Wang, XL Wu, JG Lin, TM Feng, DN Lei, XP Sun, XY Liu, W Cui, So Hrechin, SL Lv, G Niu, YW Qu   +96 more
core   +5 more sources

Cardiovascular Benefits of Salvia miltiorrhiza (Danshen) Supplementation: Bioactive Constituents, Mechanisms, Clinical Evidence and Implications for Nutritional Care

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Salvia miltiorrhiza (Danshen) contains bioactive tanshinones, including tanshinone IIA, cryptotanshinone, and tanshinone I, that exert cardioprotective effects through coordinated modulation of vascular endothelial growth factor receptor (VEGFR), transforming growth factor beta 1 (TGF‐β1), transforming growth factor beta receptor (TGF‐βR), toll‐like ...
Akash Vikal, Rashmi Maurya, Preeti Patel, Balak Das Kurmi, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Protective Effect of Salvia miltiorrhiza Extract Against Renal Ischemia-Reperfusion-Induced Injury in Rats

Molecules, 2012
The present study investigates the effect of pre-treatment with Salvia miltiorrhiza ethanol extracts (SMEE) on renal function markers, immunity and antioxidant activities in renal ischemia and reperfusion (IR) rats.
Gang Chen, Xiaohou Wu, Yunrui Fu
doaj   +1 more source

Supercritical sage extracts as anti-inflammatory food ingredients [PDF]

, 2013
This is the author’s version of a work that was accepted for publication in Industrial Crops and Products. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control ...
Arranz-Gutiérrez, Elena, Jaime, Laura, Lopez de La Hazas, Maria del Carmen, Reglero, Guillermo, Santoyo, Susana, Vicente, Gonzalo   +5 more
core   +2 more sources

A Novel Mechanism of Salvianolic Acid B in Postmyocardial Infarction Cardiac Protection: PHB1‐Driven Raf‐ERK Pathway Activation Promotes Cardiomyocyte Mitosis

MedComm, Volume 7, Issue 5, May 2026.
SalB binds to the C‐terminal of PHB1/2 heterodimer, inducing a conformational change that enhances Raf‐ERK pathway activation via Akt‐mediated phosphorylation, thereby promoting cardiomyocyte mitosis. ABSTRACT Heart failure (HF) following myocardial infarction remains a leading cause of global morbidity and mortality, necessitating novel therapeutic ...
Ce Cao, Bo Ma, Jian Zhang, Lili Yang, Zixin Liu, Haoran Li, Jianshu Song, Keer Zhang, Lei Li, Jianhua Fu, Jianxun Liu   +10 more
wiley   +1 more source

Salvia fruticosa, salvia officinalis and rosmarinic acid induce apoptosis and inhibit proliferation of human colorectal cell lines: the role in MAPK/ERK pathway [PDF]

, 2009
Epidemiologic studies have shown that nutrition is a key factor in modulating sporadic colorectal carcinoma (CRC) risk. Aromatic plants of the genus Salvia (sage) have been attributed many medicinal properties, which include anticancer activity.
Ferreira, Manuel Fernandes, Lima, Cristóvão F., Wilson, Cristina Pereira, Xavier, Cristina P. R.   +3 more
core   +1 more source