Results 221 to 230 of about 929,762 (263)

Effect of salvianolic acid A on anesthetized canine experimental myocardial infarction

China Journal of Chinese Materia Medica, 2016
Salvianolic acid A (SAA), one of the major active water-soluble salvianolic acids of traditional Chinese medicine Salvia miltiorrhiza Bunge, has been reported to be effective on anti-myocardial ischemia, anti-oxidation and anti-thrombus. This study aimed to investigate appropriate administration route on dogs with acute myocardial ischemia(AMI). Twenty-
Lei, Li, Jian-Xun, Ren, Zhi-Rong, Lin, Yue, Shi, Yan-Lei, Ma, Jian-Xun, Liu   +5 more
openaire   +2 more sources

Salvianolic acid A increases the accumulation of doxorubicin in brain tumors through Caveolae endocytosis.

Neuropharmacology, 2020
Brain glioma is one of the most common brain tumors in the central nervous system (CNS). The blood-brain tumor barrier (BTB) restricts the delivery of anti-tumor drugs into tumor tissue in the brain.
Cai Zhang, Yali Pan, Rui-ping Cai, Sirui Guo, Xiaoyi Zhang, Yixue Xue, Jiahong Wang, Jian Huang, Jinhui Wang, Yanting Gu, Zhouhai Zhang   +10 more
semanticscholar   +1 more source

[Research progress of salvianolic acid A].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2012
Salvianolic acid A is a water-soluble component from Danshen, which is frequently used in traditional Chinese medicine. High performance liquid chromatography was often used to analyze content of salvianolic acid A. The yield of salvianolic acid A increased by the technological improvement of extraction and separation.
Li, Zhang, Weiku, Zhang, Ying, Zhao, Xiuying, Yang, Lianhua, Fang, Shoubao, Wang, Lili, Shi, Xiaoyan, Yu, Subo, Wang, Haiguang, Yang, Jialin, Sun, Shuo, Tian, Guanhua, Du   +12 more
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Chemoproteomics and Phosphoproteomics Profiling Reveals Salvianolic Acid A as a Covalent Inhibitor of mTORC1

Journal of Proteome Research, 2023
Salvianolic acid A (SAA), a major active ingredient of Salvia miltiorrhiza Bunge (Danshen), displays strong antiproliferative activity against cancer cells. However, their protein targets remain unknown. Here, we deconvoluted the protein targets of SAA using chemoproteomics and phosphoproteomics.
Mengmeng Zheng, Yanmei Zhang, Yao Xu, Ying Han, Yingli Wu, Jingwu Kang   +5 more
openaire   +2 more sources

Immunomodulatory effects of Salvianolic acid B in a spontaneous abortion mouse model

Journal of Reproductive Immunology, 2020
Pregnancy is a kind of natural immune tolerance. Immune factors play an important role in recurrent spontaneous abortion and repeated implantation failure. Salvianolic acid B (SalB) has anti-tumor, anti-inflammatory, anti-oxidation and immunomodulatory functions.
Jing, Wang, Chi, Liu, Weitao, Que, Masayuki, Fujino, Guoqing, Tong, Hua, Yan, Xiao-Kang, Li   +6 more
openaire   +2 more sources

Salvianolic acid L, a potent phenolic antioxidant from Salvia officinalis

Tetrahedron Letters, 2001
Abstract Salvianolic acid L, a rosmarinic acid dimer, was isolated from Salvia officinalis and identified as 7,8-dihydroxy-2-(3,4-dihydroxyphenyl)-1,2-dihydronaphthalene-1,3-dicarboxylic acid di(1-carboxy-2-(3,4-dihydroxyphenyl))ethyl ester. Two novel hydrolytic products 7,8-dihydroxy-2-(3,4-dihydroxyphenyl)-1,2-dihydronaphthalene-1,3-dicarboxylic ...
Yinrong Lu, L.Yeap Foo
openaire   +1 more source

Metabolism of Salvianolic Acid A and Antioxidant Activities of Its Methylated Metabolites

Drug Metabolism and Disposition, 2014
This study investigated the metabolism of salvianolic acid A (SAA) both in vivo and in vitro. Liquid chromatography-mass spectrometry analysis of drug-containing rat bile samples and bile samples hydrolyzed by glucuronidase revealed a series of methylated conjugates of SAA and its glucuronides, as well as the predominance of the methylation pathway of ...
Hui, Xu, Yanli, Li, Xin, Che, Hongcui, Tian, Huaying, Fan, Ke, Liu   +5 more
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Rapid and simultaneous determination of salvianolic acid A and salvianolic acid B by complex chromatography and study on related mechanism of coordination

Analytica Chimica Acta, 2008
Abstract Salvianolic acid A (Sal A) and salvianolic acid B (Sal B) are water-soluble phenolic acids in Danshen extract and they have high medicinal value. A rapid and novel complex high-performance liquid chromatography (HPLC) method has been developed and validated for the simultaneous determination of Sal A and Sal B within 10 min.
Beibei Zhou, Jian Pan, Jia Wang
openaire   +1 more source

Cerebral Protection of Salvianolic Acid A by the Inhibition of Granulocyte Adherence

The American Journal of Chinese Medicine, 2011
Ischemic stroke is one of the most common causes of death and disability that is induced by ischemia reperfusion (IR). Granulocyte adherence has been proven to be a principal cause of IR. Salvianolic acid A (Sal A) is one of the major active components of Danshen, a Chinese herbal medicine used for the treatment of cardiovascular and cerebrovascular ...
Min, Jiang, Xiao-Ying, Wang, Wang-Yi, Zhou, Jing, Li, Jie, Wang, Li-Ping, Guo   +5 more
openaire   +2 more sources

Integrated multi-spectroscopic and molecular modelling techniques to probe the interaction mechanism between salvianolic acid A and α‑glucosidase.

Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy, 2019
α-Glucosidase (AG) is an important drug target for the treatment of type 2 diabetes mellitus in humans due to the potential effect of down regulating glucose absorption in patients.
Hongjin Tang, Fei Ma, Dongsheng Zhao
semanticscholar   +1 more source