Results 51 to 60 of about 1,088 (245)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Effect of heat treatment over the mechanical properties and the resistance to corrosion of the ternary Cu-Al-Ag alloy

Materials Research Express
In the present work, the manufacture of a Cu-9Al-3Ag alloy was carried out easily through a green molding process. After dimensioning and slitting, the alloy samples were subjected to quenching, normalizing, and annealing heat treatments, to exert phase ...
Daniel Flores-Sanchez, Miguel Ángel Suárez-Rosales, Mirella Gutiérrez-Arzaluz, Manuel Palomar-Pardavé, Mario Romero-Romo, Midori Landa-Castro   +5 more
doaj   +1 more source

Sampling-based dimension reduction for subspace approximation [PDF]

Proceedings of the thirty-ninth annual ACM symposium on Theory of computing, 2007
We give a randomized bi-criteria algorithm for the problem of finding a k-dimensional subspace that minimizesthe Lp-error for given points, i.e., p-th root of the sum of p-th powers of distances to given points,for any p ≥ 1. Our algorithm runs in time O (mn · pk3 (k/e)2p) andproduces a subset of size O (pk2 (k/e)2p) from the given points such that ...
Amit Deshpande 0001, Kasturi R. Varadarajan   +1 more
openaire   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

On Finding Hubs in High Dimensions with Sampling

Proceedings of the AAAI Conference on Artificial Intelligence
Hubs are a few points that frequently appear in the k-nearest neighbors (kNN) of many other points in a high-dimensional data set. The hubs' effects, called the hubness phenomenon, degrade the performance of kNN based models in high dimensions. We present SamHub, a simple sampling approach to efficiently identify hubs with theoretical guarantees ...
Dong H., Zeng L., Zhao Z., Silvestri F., Pham N.   +4 more
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Improved dimension dependence of a proximal algorithm for sampling

, 2023
We propose a sampling algorithm that achieves superior complexity bounds in all the classical settings (strongly log-concave, log-concave, Logarithmic-Sobolev inequality (LSI), Poincaré inequality) as well as more general settings with semi-smooth or composite potentials.
Jiaojiao Fan, Bo Yuan, Yongxin Chen
openaire   +3 more sources

Learning ridge functions with randomized sampling in high dimensions [PDF]

2012 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), 2012
We study the problem of learning ridge functions of the form f(x) = g(aT x), x ∈ ℝd, from random samples. Assuming g to be a twice continuously differentiable function, we leverage techniques from low rank matrix recovery literature to derive a uniform approximation guarantee for estimation of the ridge function f. Our new analysis removes the de facto
Tyagi, Hemant, Cevher, Volkan
openaire   +1 more source