Results 61 to 70 of about 2,520,256 (267)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Evaluation of GSJ intrusive rocks JG1, JG2, JG3, JG1a, and JGb1 by an objective outlier rejection statistical procedure

open access: yesRevista Mexicana de Ciencias Geológicas, 2018
An objective procedure involving fourteen statistical tests (a total of thirty-four variants) for detection and rejection of outliers in a univariate sample was applied to five geochemical Reference Material (RM) databases of intrusive rocks from the ...
Mirna Guevara   +2 more
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Sample Preparation for Materials Scientists [PDF]

open access: yesMicroscopy and Microanalysis, 2009
Extended abstract of a paper presented at Microscopy and Microanalysis 2009 in Richmond, Virginia, USA, July 26 – July 30 ...
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Synthesis of biowaste-derived nanostructured material for the nanomolar detection of glucose: Biological sample analysis

open access: yesJournal of Pharmaceutical and Biomedical Analysis Open
Glucose electro-oxidation in an alkaline media was investigated using an electrode composed of carbon paste and sugarcane bagasse activated carbon (SBAC). The SBAC was prepared using an easy, affordable, and environmental friendly process.
Shweta J. Malode   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

ANALYSIS OF THE ADHESION OF MICROORGANISMS TO MODERN BASIC MATERIALS IN PROSTHETIC DENTISTRY

open access: yesКубанский научный медицинский вестник, 2018
Aim. The research was conducted for the study of the adhesion of samples of the domestic modern photopolymerizable base composite material in comparison with other materials for the manufacture of the denture bases.Materials and methods.
P. S. Zudin   +7 more
doaj   +1 more source

Experimental Study on Influence of Borehole Arrangement on Energy Conversion and Acoustic Characteristics of Coal-Like Material Sample

open access: yesShock and Vibration, 2020
This paper examines the effects of borehole arrangement on the failure process of coal-like materials based on its energy conversion and acoustic characteristics from the perspectives of energy, AE energy, AE spectrum, and frequency band.
Chuanbo Hao   +3 more
doaj   +1 more source

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